Eosinophilia and skin Grunderkrankung + D72.1

Author: Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 23.01.2023

Dieser Artikel auf Deutsch


Dermatoses eosinophils; Eosinophilic dermatoses; Eosinophilic skin diseases; Hypereosinophilic dermatoses; Skin diseases eosinophils

This section has been translated automatically.

Skin manifestations characterized by eosinophilic infiltration of the skin (e.g., accompanying insect bites, drug reactions, atopic dermatitis, or other neoplastic, immmunologic, or vasculitic abnormalities) and/or by hematoeosinophilia.

Eosinophilia is the elevation of the normal value of eosinophilic granulocytes in blood (normal value: 2-4% or 50-500/µl) or tissues. Hematoeosinophilia is present when the absolute number of eosinophils of 500/µl is exceeded (> 50% of total leukocytes).

The formerly used term "hypereosinophilia" (> 1500/µl) is no longer in use and is only used nomenclatorically in the so-called hypereosinophilia syndrome.

This section has been translated automatically.

  • Primary eosinophilia:
    • clonal eosinophilia
    • idiopathic eosinophilia.
  • Secondary eosinophilia:
    • reactive eosinophilia.
  • Clonal and idiopathic forms are grouped under primary eosinophilias. Clonal eosinophilias are predominantly hematologic neoplasms or myelodysplastic and -proliferative disorders.
  • Reactive (or secondary) eosinophilias include all conditions in which a short-term or persistent eosinophilia always occurs in association with a detectable disease (e.g., parasitic disease, malignant tumors, other eosinophilic organ diseases such as eosinophilic esophagitis, gastritis, pneumonia, pancreatitis, myocarditis) or cause (e.g., drugs, radiation therapy) of nonclonal origin. Numerous dermatologic diseases are also included here (e.g., granuloma faciale).

The following is a list of diseases that are constantly or inconstantly accompanied by eosinophilia of the blood:

This section has been translated automatically.

Most common cause in Europe is allergies (> 20% of the population); increasingly, drugs are the cause of eosinophilia. Worldwide, parasitoses: depending on the region, up to 80% of the population may be affected.

This section has been translated automatically.

Procedure in case of eosinophilia:

  • Medical history (allergies, atopy, family history, medications, vaccinations, travel history).
  • Physical examination with biopsies after several days of steroid abstinence (involved organs such as: skin, heart, lungs, GIT and others).
  • Laboratory: blood count, ECP, stool tests (parasites), prick, RAST

Notice. An eosinophil count > 1500/ul is rather unusual for allergic diseases. The constellation of hematoeosinophilia and associated skin symptoms requires hematologic evaluation.

This section has been translated automatically.

A rearrangement of the genes of the "platelet-derived growth-factor receptor" (PDGFR) alpha and beta can be detected in various clonal hemato-eosinophilia. By inhibition of certain cytoplasmic tyrosinases ( imatinib) influenced by this receptor, primary eosinophilia can be successfully treated.

This section has been translated automatically.

  1. Wozel G (2007) Eosinophilic dermatoses. Dermatologist 58: 347-360


Please ask your physician for a reliable diagnosis. This website is only meant as a reference.


Last updated on: 23.01.2023