Seborrheic dermatitis of adults L21.9

Author: Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 06.09.2023

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Synonym(s)

Dermatitis dysseborrhoic; Dermatitis seborrhoic; Eczema seborrhoic; seborrheic dermatitis; Seborrheic dermatitis; seborrheic eczema; Seborrheic eczema of the adult; Seborrheic scalp eczema; seborrhoidal dermatitis; Unna's disease

History
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Plenary 1776; Unna 1886

Definition
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Common, genetically predisposed, chronic dermatitis affecting the seborrheic zones, prone to recurrence, usually relatively mild with a seasonal course (improvement in the summer months). Its independence and etiology are controversial.

Occurrence/Epidemiology
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Prevalence (Central Europe): 3-10 % of the population.

Considering the diverse spectrum of seborrheic dermatitis, including the manifestations in infancy, almost everyone has experienced this disease once.

Etiopathogenesis
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It is assumed that the disease is based on a genetic predisposition, whereby various external and internal influences (e.g. microbial colonization, climate, stress) can lead to the outbreak.

The nosological position has been disputed since the first description by Josef Jakob Plenk.

Unna described a "chronic parasitic dermatitis characterized by abnormal fat content of the most superficial epidermal layers."

In case of a dysfunction of the sebaceous glands on the one hand a minus variant of psoriasis or the initiation or the influence of the resident flora of the skin especially by Malassezia spp. (in particular Malassezia globosa) is discussed.

This still controversial etiopathogenetic connection was already suspected in 1874 by Louis-Charles Malassez, after whom Malassezia spp. are named. Versch. Investigations suggest this assumption for the infantile as well as for the adult type. However, other studies found no difference in scalp colonization between affected and unaffected individuals.

Seborrheic dermatitis occurs more frequently in HIV-infected individuals (30% of HIV patients with LAS (= lymphadenopathy syndrome) develop seborrheic dermatitis). Parkinson's disease also aggravates the disease, about 50-60 % of the patients are affected (source Arsic Arsenijevic).

In many countries there is a seasonal dependence of the disease with a peak in winter.

Manifestation
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  • Type I: Occurring in infancy, manifesting in the first 3 months of life. The clinical course is self-limiting.
  • Type II: Occurring during the 3rd-5th decade of life (phases of high sebaceous gland activity); males are affected significantly more often than females. A genetic disposition has not been described. Dry form of capillitium affection especially beyond the 5th decade of life and in senility.
  • In case of infestation of the capillitium more often sleep-deprived and stress-triggered.

Extensive, acute forms of seborrheic dermatitis should, among other things, make one think of a predisposing HIV infection.

Localization
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Seborrheic zones: face (eyebrows, nasolabial, retroauricular), often on the capillitium.

Other localizations: Beard area, intertriginous, pre-sternal, occasionally genital (especially in men), on the back.

Clinical features
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The clinical picture of seborrheic dermatitis varies according to the location:

Capillitium: The capillitium is preferentially affected. It is characterized by few, sharply defined, two-dimensional rednesses (these can also be completely absent) with dense, non-adherent, white scaling of the head (dandruff). The hairline borders are usually not crossed (DD: Psoriasis capitis, where this border is usually crossed). Itching is absent or only mild. Not infrequently, seborrheic dermatitis of the capillitium is accompanied by a presumably "inflammation-related" effluvium, which may be reversible under sufficient therapy.

The term"seborrheic eczematid" is used to describe the mildest form of seborrheic dermatitis with discrete erythema and fine scaling, which not infrequently occurs with seborrhea.

Face: The centrofacial "seborrheic skin areas" such as mid-forehead, perinasal region, also preauricular and retroauricular are affected with red, marginal, scaly plaques with varying degrees of fine to mitellamellous scaling. In some patients, preferably young women, scaly erythema is found only paranasally(erythema paranasale). The course is highly chronic (Bieber T 2018).

Eyelids: The eyelids may be affected as part of a generalized seborrheic dermatitis. However, eyelid involvement may also manifest as a monotopic course(blepharitis chronica eczematosa). Experience has shown that it is resistant to therapy and eminently persistent, especially since a long-term therapy with a corticosteroid externum has usually preceded the visit to the specialist (see also eyelid dermatitis).

Trunk: Here, the central seborrheic zones (sweat grooves in the sternal area, along the spine, shoulder girdle) are affected, sometimes also the axillae. Figured, little or no itching, scaling of varying intensity, usually localized, sharply demarcated, red or red-brown patches, papules, or confluent plaques are seen.

Some skin lesions appear marginalized and are then difficult to differentiate differentially from tinea corporis or (seborrheic) psoriasis vulgaris.

Pityriasiform seborrhoid: Very rarely, a truncal exanthematous acute or subacute course reminiscent of pityriasis rosea is observed. In contrast to pityriasis rosea, the primary plaque and a distinct collerette scaling are absent (Bieber T 2018).

Histology
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The histological picture is not specific for "seborrheic dermatitis". Usually there is a varying intensity of acanthotic widened epidermis with orthohyperkeratosis and focal parahyperkeratosis (parakeratosis mounds). Frequent loss of basket weave structure. Papillary dermis shows rather low-grade edema. Bulky, perivascularly oriented, but also diffuse predominantly lymphocytic infiltrate. Focal epidermotropy with mild (even absent) spongiosis. Biocompetent, numerous yeast elements (in the subacute form) may be seen in the keratin layer (source below).

Fact Sheet:

  • psoriasiform epidermihyperplasia
  • low-grade spongiosis with accentuation of the infundibula
  • low-grade superficial perivascular lymphocyte iniflitrate
  • Parakeratosis mound

Differential diagnosis
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Depending on the infestation pattern and localizations, different diseases come into question:

Capillitium:

  • Tinea capitis: microscopic and cell-culture proof of fungus!
  • Lichen simplex of the neck (especially in women): localized, highly pruritic, clearly infiltrated form of eczema.
  • Atopic scalp eczema: evidence of other signs of atopy; diffuse, dry and small-lamellar scaling, highly pruritic eczema
  • Pediculosis capitis: acute, usually weeping, massively pruritic dermatitis; evidence of lice (nits).
  • Contact allergic eczema of the scalp: e.g. after application of hair dyes.
  • Lichen planus follicularis capillitii: eminently chronic, frequently pruritic, rather localized clinical picture with follicular inflammation and alopecia. Typical are peripiliary scales distally confining the hair shaft with the image of "lonely hairs".
  • Pemphigus foliaceus: rare! highly inflammatory, erosive weeping; involvement of other seborrheic zones. Histological/immunohistological clarification

In other localizations:

  • Differentiation from other forms of eczema (e.g. atopic eczema, allergic dermatitis) and from psoriasis.
  • Tinea faciei: microscopic (hyphae) and cell culture evidence of fungus!
  • Tinea corporis: microscopic (hyphae) and cell culture fungal detection!

Remark. The (rather) absence of itching in seborrheic dermatitis helps in the differential diagnosis.

Complication(s)
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Seborrheic erythroderma: is one of the most common causes of erythroderma. In most cases, this universal integumentary affection is predisposed to a generalized seborrheic dermatitis (Bieber T 2018). This infestation pattern must be distinguished from a Sézary syndrome.

General therapy
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Because of the tendency to recur, the treatment of seborrhoeic eczema should always be considered as a "long-term strategy". Here, the focus is on correcting the existing seborrhoea and/or the microbial malcolonisation. The treatment principle is anti-inflammatory and antimicrobial. Due to a possible irritability of this dermatosis, aggressive treatment methods should not be applied. Treatment of infant eczema: see below Dermatitis seborrhoides infantum.

External therapy
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Capillitium: In case of light infestation, blanching, rather drying shampoos like Dermowas, mineral salt shampoos or Sebamed-liquid.

In case of moderate to severe infestation, antimycotic preparations containing azole derivatives such as ketoconazole ( Ket-Dandruff Shampoo), clotrimazole (SD-Hermal Minute Cream) or ciclopirox (e.g. Batrafen S Shampoo) or salicylic acid (Stieproxal) have proven effective.

Alternative: Tar-containing preparations such as LCD 5% in Lygal head ointment or Ichthyol® -containing preparations such as Ichthosin cream or Ichthoderm cream.

Alternatively: Zinc pyrithione or selenium disulphide containing shampoos such as Desquaman® may be helpful.

In case of a strong inflammatory component, topical glucocorticoids (e.g. Pandel cream, Ecural fat ointment or solution) may be used for a short time (!). Possibly combination preparations of glucocorticoids with added tar (e.g. Alpicort), keratolytically acting preparations with salicylic acid (e.g. Liquor carbonis detergens/Salicylic Acid Head Ointment ) or desquamating shampoos like Criniton® Hair Wash.

Facial foci: Antifungal agents such as creams containing ketoconazole or ciclopirox (e.g., Nizoral cream; Batrafen cream) are successful. Do not use ointment bases that are too oily!

Alternatively, 1-2% metronidazole creams(e.g. Metrocreme, R167 ) or gels (e.g. Metrogel).

Supplementary: In case of exacerbation, short-term (!) glucocorticoid creams such as 1% hydrocortisone buteprate or 0.05% betamethasone V lotio R030.

In seborrhoeic blepharitis: glucocorticoid-containing eye ointment (e.g. Ficortril). Good treatment results have been reported with lithium (8% lithium gluconate cream) and tacrolimus (Protopic ointment)/pimecrolimus (Elidel) therapy.

Body foci: antifungal agents such as creams containing ketoconazole (e.g. Nizoral cream). Again, no ointment bases that are too oily! Sometimes 2% clioquinol lotion R050 is also helpful, lithium-containing ointments (e.g. Efadermin) on a trial basis. Glucocorticoid creams ( glucocorticoids , topical) for a short time (!) only in case of exacerbation.

Skin cleansing: For skin cleansing alkali-free detergents (e.g. Eucerin), bath additives such as wheat bran-oat straw extract (e.g. Silvapin).

Supplementary: A mild UV therapy can be tried, but it does not lead to success in all cases. Slow dose increase is recommended; UV-induced irritations are possible.

Internal therapy
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For disseminated forms, internal therapy with glucocorticoids in medium dosages such as prednisolone (e.g. Decortin H). In case of multiple relapses, trial with tetracycline (Tetracycline Wolff Kps.) 1 g/day p.o. in week 1, 0.5 g/day p.o. in week 2 and 0.25 g/day p.o. in week 3.

Progression/forecast
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The chronic recurrent course of the disease is typical, with worsening in the winter months and often complete healing under summery, maritime climates. Thrust activities are frequently observed under beta-blocker medication (frequent constellation). Basically, the following applies: the disease can be significantly improved but not cured.

Naturopathy
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Order therapy/complementary methods:

Fatty externals should be strictly avoided, rather drying but moisturizing externals are indicated.

A balanced lifestyle, avoidance of "stress" can also help to improve the excessive sebum production. Nutritional therapy: whole food diet with fresh fruits and vegetables.

Hydrotherapy: dehydration with oak bark extract as a poultice or O/W emulsion (e.g. Tannolact® (cream/Lotio): contains as active ingredient a synthetic tannin, a sulfonated phenol-methanal-urea polycondensate).

Washes with fragrance-free shower gels containing Dead Sea salt have a disinfecting and drying effect.

Homeopathic therapy:

Mahonia (Mahonia aquifolium) has antiphlogistic, antiproliferative, antibacterial, antiseborrheic and keratolytic effects. All components of the plant (root bark, stems, leaves) are used. As a homeopathic with 10% mother tincture, available as Rubisan® ointment N/cream 2-3 x/day, can alleviate eczema.

Cardiospermum halicacabum (balloon vine) extracts exhibit an antiphlogistic effect due to their content of saponins, alkaloids, flavonoids and tannins, which has proven useful in seborrheic eczema. Cardiospermum halicacabum leaf extracts are commercially available (e.g., as homeopathics Dermaplant® Ointment and Halicar® Ointment; both contain 10% mother tincture and antiseptic-acting benzyl alcohol/benzoate).

Astringent compresses, e.g. with oak bark extracts or black tea (alternatively green tea), have proved effective in reducing the fat content.

Pansy herbas a tea infusion has an antiphlogistic effect, see also Violae herba cum flore.

Scientific nutritional medicine

Deficiency of vit. B2 riboflavin more often than vit. B5 panthotenate, vit. B6 pyridoxine, vit. B7 biotin, vit. D colecalciferol/cholecalciferol, copper Cu or zinc Zn contributes to the disease or/and makes severe/-re courses, hinders healing despite standard therapy.

Tables
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Localization

Vehicle

Active ingredients

Example preparations

Scalp foci

Complex ointments/gels/shampoos/solutions

Ketoconazole

Ket Shampoo

Ciclopiroxolamine

Batrafen shampoo, Sebiprox solution

Salicylic acid

Criniton, Squamasol

Zinc Pyrithione

Desquaman

Selenium sulfide

Selsun, Selukos

Sulphur

Diasporal

Coal tar

Tarmed

Without additive

Dermowas, Physiogel

Creams/ointments/tinctures

Salicylic acid

Squamasol, Lygal head ointment

Glucocorticoids

Ecural, Dermatop

Prednisolone

Lygal head tincture

Prednisolone, salicylic acid

Alpicort solution

Creams

Ammonium Bituminosulfonate

Ichthosin, Ichthoderm,

133

Facial herbs

Tinctures/gels/solutions/creams/lotions

Ketoconazole

Nizoral, Terzolin

Metronidazole gel

Metro Gel

Metronidazole Cream

Metro Cream

Erythromycin solution

Aknemycin

Erythromycin gel

Eryacne 2-4%

Salicylic acid ethanol gel

Ethanol-containing salicylic acid gel 6% (NRF 11.54.)

Salicylic acid, Na-bituminosulfonate

Aknichthol Soft Lotio

Body lotions

Creams/Ointments

Ketoconazole Cream

Nizoral Cream

Ciclopiroxolamine Cream

Batrafen Cream

Metronidazole cream

Metro Cream

Erythromycin cream

Aknemycin cream

Lithium ointment

Efadermin ointment

Clotrimazole cream

SD-Hermal Minute Cream

Lotions

Clioquinol lotion (if necessary additionally ichthyol, sulphur)

Bath additives

Wheat bran- oat straw extract

Silvapin

without special additives

Dermowas, Satina, Sebamed

Note(s)
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Inform the patient about possible worsening of the skin condition due to excessive alcohol consumption, consumption of fatty or strongly spiced food.

Literature
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  1. Barac A et al. (2015) Presence, species distribution, and density of Malassezia yeast in patients with seborrheic dermatitis - a community-based case-control study and review of literature. Mycoses 58: 69-75
  2. Bieber T (2018) Other forms of dermatitis. In: Braun-Falco`s Dermatology, Venereology Allergology G. Plewig et al (eds) Springer Verlag pp 571-576.
  3. Borda LJet al (2015) Seborrheic dermatitis and dandruff: A Comprehensive Review. J Clin Investig Dermatol 3:2.
  4. Braza TJ et al (2003) Tacrolimus 0.1% ointment for seborrheic dermatitis: an open-label pilot study. Br J Dermatol 148: 1242-1244.
  5. Dreno B et al (2003) THE STUDY INVESTIGATOR GROUP. Lithium gluconate 8% vs ketoconazole 2% in the treatment of seborrhoeic dermatitis: a multicentre, randomized study. Br J Dermatol 148: 1230-1236.
  6. Faergemann J (2001) Treatment of seborrhoeic dermatitis with oral terbinafine? Lancet 358: 170
  7. Moises-Alfaro CB et al (2002) Are infantile seborrheic and atopic dermatitis clinical variants of the same disease? Int J Dermatol 41: 349-351
  8. Moraes AP de et al (2007) An open-label efficacy pilot study with pimecrolimus cream 1% in adults with facial seborrheic dermatitis infected with HIV. JEAV 21: 596-601
  9. Ooi ET et al (2014) Improving the management of seborrheic dermatitis. Pract 258:23-26
  10. Okokon EO et al (2015) Topical antifungals for seborrhoeic dermatitis. Cochrane Database Syst Rev 5 PubMed PMID: 25933684.
  11. Plenck JJ (1776) Doctrine de morbis cutaneis. Rodolphum Graeffer, Vienna
  12. Ramos-E-Silva M et al (2014) Red face revisited: endogenous dermatitis in the form of atopic dermatitis and seborrheic dermatitis. Clin Dermatol 32:109-115
  13. Sticherling M (2017) Psoriasis capitis and seborrheic eczema of the scalp. Dermatol 68: 457-468
  14. Unna PG (1886) The seborrheic eczema. Monatshefte für praktische Dermatologie 6: 829-846.
  15. Warshaw EM et al (2007) Results of a randomized, double-blind, vehicle controlled efficacy trial of pimecrolimus cream 1% for the treatment of moderate to severe facial seborrheic dermatitis. J Am Acad Dermatol 57: 257-264.
  16. Wilsmann-Theis D et al (2014) Psoriasis and eczema of the capillitium. Dermatologist 65: 1043-1049

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