DefinitionThis section has been translated automatically.
Halogenated glucocorticoid. The only betamethasone derivative that is used in magistral formulations as a medium-strength (class II) glucocorticoid in a 0.05% concentration and as a strong (class III) external glucocorticoid in a 0.1% concentration! Betamethasoen-17-valerate has a pH-stability optimum at pH 3.5. In the strongly acidic as well as in the neutral or alkaline range the molecule undergoes a so-called isomerization. The valerate residue moves from the C-17 atom to the C-21 atom. This causes the glucocorticoid to lose about 85% of its effectiveness. For this reason the NRF uses a citrate buffer (pH 4.2) for stabilization in the"hydrophilic betamethasone valerate cream (NRF 11.37.) and in the hydrophilic betamethasone valerate emulsion.
IndicationThis section has been translated automatically.
Eczema, allergic skin reactions, in persistent cases also short-term as interval or tandem therapy for psoriasis vulgaris.
Notice! Application duration max. 4 weeks!
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Limited indicationThis section has been translated automatically.
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Recipe(s)This section has been translated automatically.
- Betamethasone valerate emulsion, hydrophilic (NRF 11.47.)
- Betamethasone valeratecream, hydrophilic (NRF 11.37.)
- Betamethasonevalerate cream (0.05-0.1% W/0)
- A 0.1% hydrophilic betamethasone valerate emulsion can be combined with 5-10% urea. To prevent degradation of the urea into its parent substances in this emulsion, the addition of a lactate buffer (1% lactic acid and 4% sodium lactate solution) is recommended.
- Urea pura 10.0 g
- Acid lact 2,0 g
- Sodium lact 50% 8.0 g
- Betamethasone valerate emul. 0.1% NRF 11.47. ad 200.0 g
S.: 01% betamethasone valerate - 10% urea emulsion; expiry date 6 months (plastic bottle)
PreparationsThis section has been translated automatically.
LiteratureThis section has been translated automatically.
Wolf g (2012) Inhomogeneities in individual formulations. dermatologist 63: 518-519