Betamethasone valerate

Halogenated glucocorticoid. The only betamethasone derivative that is used in magistral formulations as a medium-strength (class II) glucocorticoid in a 0.05% concentration and as a strong (class III) external glucocorticoid in a 0.1% concentration! Betamethasoen-17-valerate has a pH-stability optimum at pH 3.5. In the strongly acidic as well as in the neutral or alkaline range the molecule undergoes a so-called isomerization. The valerate residue moves from the C-17 atom to the C-21 atom. This causes the glucocorticoid to lose about 85% of its effectiveness. For this reason the NRF uses a citrate buffer (pH 4.2) for stabilization in the"hydrophilic betamethasone valerate cream (NRF 11.37.) and in the hydrophilic betamethasone valerate emulsion.

Eczema, allergic skin reactions, in persistent cases also short-term as interval or tandem therapy for psoriasis vulgaris.

Notice! Application duration max. 4 weeks!

• Betamethasone valerate emulsion, hydrophilic (NRF 11.47.)
• Betamethasone valeratecream, hydrophilic (NRF 11.37.)
• Betamethasonevalerate cream (0.05-0.1% W/0)
• A 0.1% hydrophilic betamethasone valerate emulsion can be combined with 5-10% urea. To prevent degradation of the urea into its parent substances in this emulsion, the addition of a lactate buffer (1% lactic acid and 4% sodium lactate solution) is recommended.
• Rp
  • Urea pura 10.0 g
  • Acid lact 2,0 g
  • Sodium lact 50% 8.0 g
  • Betamethasone valerate emul. 0.1% NRF 11.47. ad 200.0 g

S.: 01% betamethasone valerate - 10% urea emulsion; expiry date 6 months (plastic bottle)

Wolf g (2012) Inhomogeneities in individual formulations. dermatologist 63: 518-519