Betamethasone valerate

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

betamethasone 17-valerate; Betamethasone V

Definition
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Halogenated glucocorticoid. The only betamethasone derivative which is used in a 0.05% concentration as a medium-strength (class II) in a 0.1% concentration as a strong (class III) external glucocorticoid in magistral prescriptions! Betamethasoen-17-valerate has an optimum pH stability at pH 3.5. The molecule undergoes so-called isomerisation in the strongly acidic as well as in the neutral or alkaline range. The valerate residue migrates from the C-17 atom to the C-21 atom. This causes the glucocorticoid to lose about 85% of its effectiveness. For this reason, the NRF uses a citrate buffer (pH 4.2) for stabilisation in the"hydrophilic betamethasone valerate cream (NRF 11.37.) and in the hydrophilic betamethasone valerate emulsion.

Indication
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Eczema, allergic skin reactions, in persistent cases also short-term as interval or tandem therapy for psoriasis vulgaris.

Notice! Application duration max. 4 weeks!

Limited indication
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Long-term therapy for children and the face.

Dosage and method of use
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Apply thinly 1-2 times/day to the affected skin areas.

Standard concentration
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0.05-0.1% as cream, ointment, lotion, solution.

Contraindication
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Infants < 12 months, pruritus anogenitalis, acne.

Recipe(s)
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  • Betamethasone valerate emulsion, hydrophilic (NRF 11.47.)
  • Betamethasone valerate cream, hydrophilic (NRF 11.37.)
  • cream of betamethasone val erate (0,05-0,1% W/0)
  • A 0.1% hydrophilic betamethasone valerate emulsion can be combined with 5-10% hemp. In order to prevent degradation of the urea into its starting materials in this emulsion, the addition of a lactate buffer (1% lactic acid and 4% sodium lactate solution) is recommended.
  • Rp
    • Urea pura 10,0 g
    • Acid lact 2,0 g
    • Natr.lact 50% 8,0 g
    • Betamethasone valerate emulsion 0,1% NRF 11.47. ad 200,0 g

S. 01% betamethasone valerate - 10% urea emulsion; use-by period 6 months (plastic bottle)

Preparations
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Betnesol-V, Beta-Wolff, Betagalen, Celestan-V, Cordes Beta, Linola Beta, Fucicort (combination with fusidic acid)

Literature
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Wolf g (2012) Inhomogeneities in individual formulations. dermatologist 63: 518-519

Authors

Last updated on: 29.10.2020