Betamethasone valerate emulsion hydrophilic 0,025/0,05 or 0,1 % (nrf 11.47.)

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Betamethasone emulsion; Hydrophilic betamethasone valerate emulsion; NRF11.47.

Formulation
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Rp.

Betamethasone 17-valerate 0,025/0,05/0,1
Sorbitan monostearate 2,0
macrogol-8-stearate 2,0
Medium chain triglycerides 5,0
glycerol 85% 5,0
Potassium sorbate 0,14
Citric acid, anhydrous 0,07
Aqua purif.ad100,0

Hydrophilic, non-ionic betamethasone valerate lotio of type O/W (containing cortisone) for external use. Apply a thin layer initially 2 times/day, then 1 time / day to the diseased skin areas.

Period of use: 6 months

Remark: Betamethasone valerate tends to isomerize in strongly acidic and alkaline environments (Wolf G 2014). The molecule loses about 85% of its effect. Therefore, NRF 11.47. as well as the hydrophilic cream of betamethasone valerate (NRF 11.37.) provides for the addition of a citrate buffer (pH 4.2).

Lit.: Wolf G (2014) Complex interactions between active substance and base. Dermatologist 65: 486-487

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Last updated on: 29.10.2020

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