Ketoconazole

Imidazole antifungal.

2 h or 6-10 h (metabolites).

Inhibition of the ergosterol synthesis of the fungal cell membrane of dermatophytes, yeasts and moulds.

Mycoses of the skin, hair and mucous membrane, caused by dermatophytes, candida and other pathogens. Organ and system mycoses, fungal prophylaxis, chronic recurrent vaginal mycoses.

Diabetes mellitus, nursing.

• Topical:
• Mycoses and candidoses of the skin: Apply cream thinly to the affected areas 1-2 times/day for 2-3 weeks or apply solution once/day for max. 5 days.
• Seborrheic eczema: Cream: Apply 2 times/day for 4 weeks on the affected areas. Solution: 2 times/week for 2-4 weeks, apply half a cap to damp hair, massage in, leave on for 3-5 minutes, then rinse with warm water. To prevent recurrence, apply at 1-2 weekly intervals for 4 months.
• Systemic:
• 1 time a day 200 mg p.o. for 1-2 months.
• Vaginal mycoses: 1 time per day 400 mg p.o. for 5-10 days.
• Children from 2 years up to 20 kg KG: once/day 50 mg p.o.
• Children up to 30 kg KG: once/day 100 mg p.o.

Remember! Exclude pregnancy by pregnancy test before the therapy. Women of childbearing age must use effective contraception during the therapy!

2% as cream or solution.

• Top. Anw.: Allergic reactions.
• Syst. Anw: Pruritus, alopecia, allergic to anaphylactic reactions, hepatocellular necrosis 1:1000, abdominal pain, nausea, constipation, gynecomastia.

s. Table 1.

• Topical: Use on the eye, imidazole hypersensitivity.
• Systemic: Imidazole hypersensitivity, chron. alcohol abuse, acute or chronic liver disease, pregnancy, prostate cancer.

Nizoral®, Terzolin®

Main interactions of ketoconazole