Artemether/lumefantrine

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Spectrum of action
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Effective against sexually mature forms (gametocytes) of Pl. falciparum (also for chloroquine resistance).

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Indication
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Acute, uncomplicated malaria tropica (Pl. falciparum) in patients > 12 years and > 35 kg bw.

Notice! Not suitable for malaria prophylaxis!

Dosage and method of use
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Adults/children > 12 years and > 35 kg bw: 6 times 4 tablets (20 mg artemether/120 mg lumefantrine per tablet) over a total of 60 hours (ED with 4 Tbl. each at the start of therapy, after 8, 24, 36, 48 and 60 hours). To be taken with a high-fat meal!

Notice! In case of vomiting of the medication within 1-3 hours after application, repeat the intake!

Undesirable effects
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Headache, dizziness, abdominal pain, loss of appetite, nausea, myalgia, pruritus, skin changes.

Contraindication
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Complicated malaria tropica, cardiac arrhythmias, comedication with CYP2D6 substrates (e.g. amitriptyline, metoprolol) or CYP3A4 inhibitors (e.g. erythromycin, ketoconazole, itraconazole)

Preparations
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Riamet

Note(s)
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Remember! For patients with severe kidney or liver dysfunction: ECG and laboratory tests!

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Malaria;

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Last updated on: 29.10.2020