Synonym(s)
HistoryThis section has been translated automatically.
DefinitionThis section has been translated automatically.
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EtiopathogenesisThis section has been translated automatically.
Unexplained; T-cell defects and functional disorders of the eosinophilic granulocytes have been demonstrated. Also occurred after taking ECE inhibitors.
ManifestationThis section has been translated automatically.
Clinical featuresThis section has been translated automatically.
Mostly dramatic, recurrent (monthly intervals; also more often), most severe swelling of the face, neck, extremities and trunk. These episodic angioedema can be combined with high fever attacks, arthralgias, weight loss. The episodes can also occur after infections.
LaboratoryThis section has been translated automatically.
Differential diagnosisThis section has been translated automatically.
TherapyThis section has been translated automatically.
The clinical picture responds well to higher and medium doses of glucocorticoids (e.g. prednisolone 1.0-1.5 mg/kg bw/day).
Occasionally, success with IVIG has also been described.
A case report is available on effects with "Suplatast tosilate", an anti-allergic Th2 cytokine inhibitor.
Note(s)This section has been translated automatically.
LiteratureThis section has been translated automatically.
- Abouzahir A et al (2005) Equal syndromes. A case report and review of the literature. Rev Med Internal 26: 137-140
- Banerji A et al (2006) Cytokine-associated angioedema syndromes including episodic angioedema with eosinophilia (Gleich's syndrome). Immunol Allergy Clin North Am 26: 769-81
- Equals GJ, Schroeter AL, Marcoux JP, Sachs MI, O'Connell EJ, Kohler PF (1984) Episodic angioedema associated with eosinophilia. Trans Assoc Am Physicians. 97: 25-32
Hashizume H et al (2014) Treatment of non-episodic angioedema associated with eosinophilia with suplatast tosilate, an anti-allergic selective Th2 cytokine inhibitor. Eur J Dermatol 24:250-252
- Motegi S et al (2013) Elevated serum levels of TARC/CCL17, eotaxin-3/CCL26 and vascular endothelial growth factor in a patient with non-episodic angioedema associated with eosinophilia and granulomatous cutaneous reaction. Eur J Dermatol 23:524-526
- Panaszek B et al (2003) Blood and tissue eosinophilia in patient with angioedema caused by inhibitor of angiotensin converting enzymes (ACE). Pol Arch Med Wewn 110: 1339- 1343
- Stockner I et al (2008) Non-episodic angioedema associated with eosinophilia following Mycoplasma pneumoniae infection. Clin Rheumatol 27:1573-1576
Incoming links (4)
Capillary leak syndrome; Capillary leak syndrome; Eosinophilia skin changes; Hypereosinophilia syndrome;Outgoing links (5)
Capillary leak syndrome; Eosinophilia skin changes; Hypereosinophilia syndrome; Interleukin-2 therapy; Ivig;Disclaimer
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