DefinitionThis section has been translated automatically.
Differently defined group of diseases. Originally, the adjective "acquired" was used to refer to "acquired C1-esterase inhibitor deficiency" and thus was used in opposition to hereditary angioedema (see below complement system). However, "acquired" forms of angioedema in the broader sense also include:
- Histamine-mediated angioedema without C1-INH deficiency (often partial picture or equivalent of acute or chronic urticaria).
- Idiopathic angioedema without C1-INH deficiency
- Drug-induced angioedema without C1-INH deficiency (pharmacologically induced by drug inhibition of the renin-angiotensin system - ACE inhibitors/angiotensin II receptor blockers; they are bradykinin-mediated)
- Trauma-induced angioedema.
ClassificationThis section has been translated automatically.
Type I (acquired angioedema, AAE I): partly with lymphoproliferative malignancies, e.g. malignant lymphoma.
Type II (AAE II): like AAE I, detectable antibodies against C1-INH.
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EtiopathogenesisThis section has been translated automatically.
Quantitative and/or functionalC1 esterase inhibitor deficiency. Pronounced C1q deficiency.
Furthermore, the formation of antibodies against the active site of theC1 inhibitor as well as the activation of the complement cascade by anti-idiotypic antibodies with excessive consumption (AAE type II) are described.
ManifestationThis section has been translated automatically.
Clinical featuresThis section has been translated automatically.
LaboratoryThis section has been translated automatically.
TherapyThis section has been translated automatically.
See below Angioedema hereditary.
LiteratureThis section has been translated automatically.
- Kirkup ME et al (2003) Experience with tranexamic acid for nonheriditary angio-oedema and urticaria. Br J Dermatol 149 (Suppl 64): 25-26
- Nashan D et al (1995) Life-threatening angioedema due to acquired C1-inhibitor deficiency associated with paraproteinemia and livedo racemosa. Dermatologist 46: 339-342
- Nettis E (2003) Clinical and aetiological aspects in urticaria and angio-oedema. Br J Dermatol 148: 501-506
- Netzwerk aktuell (2010) Angioedema caused by hawthorn extract (Crataegutt Novo). Medication telegram 41: 54
Incoming links (12)Angioedema acquired/mast cell degranulation; Angioedema episodic with eosinophilia; Angioedema idiopathic; Angioedema of the head and neck region; At1 receptor antagonists; Bannister's disease; Bradykinin; Complement system; Panniculitis histiocytic, cytophagic; PID; ... Show all
Outgoing links (9)ACE inhibitor-induced angioedema; Angioedema hereditary ; Angioedema hereditary 1; Angioedema histamine-mediated; Angioedema idiopathic; Angioedema, vibratory; Ciclosporin a; Complement system; Urticaria (overview);
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