Angioedema acquired/mast cell degranulation T73.3

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Acquired angioedema at the bottom of a mast cell degranulation. Mostly at the base of a type I reaction or intolerance reaction to protein components in food and drugs (especially salicylates, preservatives) as well as physical stimuli (vibration, pressure), often the etiology remains unclear.

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  • Cooling. If triggered by medication, discontinue medication. Glucocorticoids such as prednisolone (e.g. Solu-Decortin H) initial 250 mg i.v., for severe reactions up to 1.0 g/day i.v. Gradual reduction depending on the clinic. In emergency situations, the administration of a drinking cortisone (Celestamine N liquidum) has proven to be effective. This can be prescribed to patients with known and recurrent angioedema.
  • Additionally, antihistamines such as dimetinden (e.g. Fenistil) initially 1-2 amp/day i.v., reduction according to clinic. In case of complications such as laryngeal edema, glottis edema, immediate intensive care measures! For emergency situations, use a ready-to-use adrenaline syringe(e.g. Anapen, Fastject).
S.a. shock, anaphylactic.


Please ask your physician for a reliable diagnosis. This website is only meant as a reference.


Last updated on: 29.10.2020