DefinitionThis section has been translated automatically.
Acute or chronic, non-immunological, dose-dependent, biological reaction form that mimics an allergic reaction and has no relation to pharmacological toxicity in the case of triggering drugs. Enzymatically triggered reactions such as lactose intolerance or ACE-induced angioedema are also considered intolerance reactions.
EtiopathogenesisThis section has been translated automatically.
Mechanisms and causes of intolerance reactions:
- Mediator release from mast cells: tartrazine (?), antibiotics, muscle relaxants, opioids.
- Influence on the metabolism of arachidonic acid: X-ray contrast media, analgesics (e.g. salicylates), anti-inflammatory drugs, food dyes (?), benzoates(?), parabens (?).
- Complement activation: immunoglobulin aggregates, X-ray contrast agent, protamine.
- Kinin activation: local anesthetics, ACE inhibitors.
- Lymphocyte activation: ampicillin, hydantoin.
- Release of neurotransmitters: erythrosine, glutamate.
- Excitation of autonomic receptors: sulphites, glutamate, local anaesthetics
- Activation of the MRGPRX2 receptor (plays a role in the intolerance reaction to ciprofloxacin)
Clinical featuresThis section has been translated automatically.
LiteratureThis section has been translated automatically.
- Ring J et al (2018) Immediate type allergy: Rhinoconjunctivitis, bronchial asthma, anaphylaxis. In: Braun-Falco`s Dermatology, Venerology Allergology G. Plewig et al. (Hrsg) Springer Verlag S 454
Incoming links (30)Acetylsalicylic acid; Allergen; Allergen; Allura red ac; Amines, biogenic; Analgesic intolerance syndrome (ais); Angioedema acquired/mast cell degranulation; Cast; Cast; China spice syndrome; ... Show all
Outgoing links (9)Amines, biogenic; Anaphylactic shock; Angioedema (overview); Ciprofloxacin; Immunological drug reactions; Mrgprx2; Salicylates; Urticaria chronic spontaneous; Urticaria intolerance urticaria;
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