Cutaneous vascular tumors (overview) L98.9

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

cutaneous hemangioma; Hemangiomas; vascular tumors of the skin

Definition
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The common classifications of cutaneous vascular tumors are based on morphological, clinical and histological criteria. In the case of vascular proliferates that appear clinically as a "tumour", it is often unclear whether they are:...a tumor. Another special etiopathogenetic and clinical feature is the infant hemangioma.

Classification
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Histology
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Structural composition of vascular tumours:

  • Vascular orientation (intra- or perivascular)
  • Architecture (lobar or nodular/diffuse)
  • Endothelial pattern (single layer or papillary multilayer)
  • Vascular structure (organoid capillary vessels or bizarre vascular structures).

immunohistology:

  • Immunohistologically intravascular angiomas are defined as descendants of blood or lymph vessel endothelia, perivascular angiomas as descendants of smooth muscle cells or pericytes.
  • Markers for endothelia are: CD31, ERG, FLI-1, factor VII-related antigen/v. Willebrand factor), CD34, Ulex europaeus.
  • Markers for lymphatic endothelia are: D2-D40/Podoplanin, Prox1, LYVE1, VEGFR3 (vascular endothelial growth factor-3)
  • In perivascular angiomas, reactivities for alpha smooth muscle actin, desmin, calponin, caldesmon are found.

Literature
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  1. Kutzner H (2003) Vascular tumors of the skin. In: Kerl H et al (Ed.) Histopathology of the skin. Springer Publishing House, Berlin Heidelberg New York, S. 759
  2. North PE et al (2003) Vascular neoplasms and neoplastic - like proliferations. In: Bologna J et al (ed.) Dermatology. Mosby, London New York Toronto, S. 1818

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020