Cutaneous vascular tumors (overview) L98.9

Author: Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 17.01.2023

Dieser Artikel auf Deutsch


cutaneous hemangioma; Hemangiomas; vascular tumors of the skin

This section has been translated automatically.

Common classifications of cutaneous vascular tumors are based on morphologic, clinical, and histologic criteria. Vascular proliferations that appear clinically as "angiomatous tumors" are often unclear as to whether they are:

are involved. Hemangioma of the infant occupies a special etiopathogenetic and clinical position.

This section has been translated automatically.

This section has been translated automatically.

Structural composition of vascular tumours:

  • Vascular orientation (intra- or perivascular)
  • Architecture (lobar or nodular/diffuse)
  • Endothelial pattern (single layer or papillary multilayer)
  • Vascular structure (organoid capillary vessels or bizarre vascular structures).


  • Immunohistologically intravascular angiomas are defined as descendants of blood or lymph vessel endothelia, perivascular angiomas as descendants of smooth muscle cells or pericytes.
  • Markers for endothelia are: CD31, ERG, FLI-1, factor VII-related antigen/v. Willebrand factor), CD34, Ulex europaeus.
  • Markers for lymphatic endothelia are: D2-D40/Podoplanin, Prox1, LYVE1, VEGFR3 (vascular endothelial growth factor-3)
  • In perivascular angiomas, reactivities for alpha smooth muscle actin, desmin, calponin, caldesmon are found.

This section has been translated automatically.

  1. Kutzner H (2003) Vascular tumors of the skin. In: Kerl H et al (Ed.) Histopathology of the skin. Springer Publishing House, Berlin Heidelberg New York, S. 759
  2. North PE et al (2003) Vascular neoplasms and neoplastic - like proliferations. In: Bologna J et al (ed.) Dermatology. Mosby, London New York Toronto, S. 1818


Please ask your physician for a reliable diagnosis. This website is only meant as a reference.


Last updated on: 17.01.2023