Mibelli's angiokeratoma D23.L7

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

angiokeratoma acroasphycticum digitorum; Mibelli type angiokeratosis; Mibell's disease

History
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Cottle, 1879; Mibelli, 1889

Definition
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Rare, autosomal-dominant, gynecotropic hereditary disease characterized by acrally localized multiple angiokeratomas.

Manifestation
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First occurrence often during puberty; mainly in vagotonic patients with cold intolerance and tendency to acrocyanosis and frostbite.

Localization
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Acral preference; especially fingers and toes, also elbows and knees.

Clinical features
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Mostly symmetrically arranged, at first flat, pinhead to lenticular erythema, later on blue-red papules with rough, sometimes also woolly surface.

Histology
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Circumscribed cavernous extensions of capillary loops, acanthotic, hyperkeratotic epidermis.

Differential diagnosis
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Therapy
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If necessary, diathermy, laser treatment or excision if desired.

Literature
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  1. Cottle W (1879) Warty growths. St. Georges Hospital Reports 9: 753-762
  2. L'angiocheratoma. Giornale italiano di dermatologia e venereologia (Turin) 26: 159-180 and 260-276
  3. Mibelli V (1889) Di una nuova forma di cheratosi angiocheratoma. Giornale italiano di dermatologia e venereologia (Turin) 30: 285-301
  4. Sommer S et al (2001) Severe predominantly acral variant of angiokeratoma of Mibelli: response to long-pulse Nd:YAG (1064 nm) laser treatment. J Am Acad Dermatol 45: 764-766

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Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020