Angiosarcoma radiation-induced C44.-

Rapidly growing tumour with firm, red or reddish-brown papules and nodes, appearing 1-10 years after irradiation. Metastasis: haematogen. Radiation-induced angiosarcoma must be distinguished from the pseudomalignant "atypical vascular lesion".

Formation of bizarre, labyrinth-like, irregularly dilated, lymphatic vessels with protuberant or freely floating endothelial proliferates (lymphatic-endothelial immune phenomenon type: podoplanin positive) Significant nuclear polymorphism of the endothelia. The proliferation factor Ki-67 is significantly increased. Cytogenetic: MYK expression.

Very bad. Life expectancy < 2 years.

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