Angiosarcoma of the breast region; angiosarcoma postradiation; radiation-induced angiosarcoma
DefinitionThis section has been translated automatically.
Highly malignant vascular tumor occurring in thoracic and abdominal radiation fields.
ManifestationThis section has been translated automatically.
Middle-aged, women mainly affected.
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LocalizationThis section has been translated automatically.
Clinical featuresThis section has been translated automatically.
Rapidly growing tumour with firm, red or reddish-brown papules and nodes, appearing 1-10 years after irradiation. Metastasis: haematogen. Radiation-induced angiosarcoma must be distinguished from the pseudomalignant "atypical vascular lesion".
HistologyThis section has been translated automatically.
Formation of bizarre, labyrinth-like, irregularly dilated, lymphatic vessels with protuberant or freely floating endothelial proliferates (lymphatic-endothelial immune phenomenon type: podoplanin positive) Significant nuclear polymorphism of the endothelia. The proliferation factor Ki-67 is significantly increased. Cytogenetic: MYK expression.
Differential diagnosisThis section has been translated automatically.
TherapyThis section has been translated automatically.
Excision by specialists.
Progression/forecastThis section has been translated automatically.
Very bad. Life expectancy < 2 years.
LiteratureThis section has been translated automatically.
- Chow W et al (2015) Growth Attenuation of Cutaneous Angiosarcoma With Propranolol-Mediated β blockade. JAMA Dermatol 151: 1226-1229.
- Cornejo KM et al. (2015) The utility of MYC and FLT4 in the diagnosis and treatment of postradiation atypical vascular lesion and angiosarcoma of the breast. Hum Pathol 46: 868-875.
- Grebić D et al (2015) Sporadic Case of Breast Angiosarcoma as a Complication of Radiotherapy Following Breast-Conserving Surgery for Invasive Ductal Breast Cancer. Breast Care (Basel) 10: 336-338.
- Rallabandi HB et al (2016) Postradiation angiosarcoma of bladder with extensive osseous metaplasia. Indian J Pathol Microbiol 59:78-80.
- Zatloukal A et al (2016) Secondary angiosarcoma of the abdominal wall after adjuvant radiotherapy in a patient with uterine carcinoma - a case report. Rozhl Surgeon 95:131-133.
Incoming links (2)Atypical vascular lesion; Radiation induced angiosarcoma;
Outgoing links (2)Excision; Radiodermatitis chronic;
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.