Deposit dermatoses (overview) L98.9

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Deposit dermatoses; Deposit dermatoses exogenous; Deposition dermatoses endogenous; endogenous; exogenous

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Heterogeneous group of etiologically different diseases characterized by the deposition of endogenous or also exogenous substances in the dermis and/or subcutis.

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Classification of endogenous and exogenous deposition dermatoses:

Deposited substance Disease
Endogenous deposition dermatoses
Amyloid Amyloidosis, cutaneous
Amyloidosis, systemic
AA-type amyloidosis
AL-type amyloidosis
Amyloidosis cutis nodularis atrophicans
Amyloidosis, macular
lichen amyloidosis
Amyloidosis, perforating cutaneous
Amyloidosis, blistering
Muckle-Wells Syndrome
Colloid Colloidalmilium
Colloidalmilium, juveniles
Hyaline Hyalinosis cutis et mucosae
Lipoid proteinosis in photosensitivity
Moschcowitz Syndrome
Muzin Mucinoses
REM syndrome
lichen myxoedematosus
myxoedema circumscriptum symmetricum praetibiale
Plaque-like form of cutaneous mucinosis
Myxoedema, diffuse
Dorsal cyst, mucoid
follicular mucinosis
Calcium salts calcinosis metastatica
calcinosis cutis
calcinosis dystrophica
Uric acid crystals Gout
Gouty Tophi
Homogentisic acid Ochronosis
Oxalate crystals Oxalosis
Lipids Xanthom
Histiocytoses, non-Langerhans cell histiocytoses
Xanthogranuloma, juveniles (sensu strictu)
Xanthogranuloma, necrobiotic with paraproteinemia
Xanthomatosis, generalized plane
Xanthome, eruptive
Xanthoma, papular
Xanthoma, tuberous
Xanthomatosis, normolipemic, subcutaneous
Dermatofibroma, xanthomatized
Tangier Disease
Ceramide Lipogranulomatosis, disseminated
Sphingolipids Sphingolipidoses
Angiokeratoma corporis diffusum (Fabry disease)
M. Gaucher
Aspartyl glucosaminuria
Niemann-Pick disease
Lipogranulomatosis, disseminated (M. Farber)
Kanzaki disease
Exogenous deposition dermatoses
Silver Argyrie
Gold Chrysiasis
Mercury Hydrargyrosis
Cutaneous implants paraffin, silicone; bioplastics

Clinical features
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Deposit dermatoses are easily recognizable from a clinical perspective. Unnatural discolorations of the skin indicate deposits of colored substances. Palpable, unaccustomed increases in consistency indicate accumulations of foreign substances (calcifications, ossifications, amyloid and others). In everyday clinical practice, such a finding provides histological clarification.

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In endogenous deposition dermatoses, the body's own degradation products or incorrectly formed substances (e.g. amyloid) are deposited. It is often unclear whether increased formation or reduced breakdown is responsible for the deposition.

In exogenous deposition dermatoses, substances introduced from outside remain in the skin.

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  1. Müller CSL et al (2016) Cutaneous deposition dermatoses - the skin as a waste bin? What should the clinician know? Act Dermatol 42: 79-89


Please ask your physician for a reliable diagnosis. This website is only meant as a reference.


Last updated on: 29.10.2020