HistoryThis section has been translated automatically.
DefinitionThis section has been translated automatically.
Cutaneous amyloidosis with mostly extensive, little or slightly itchy, brownish or greyish-brownish patches or plaques. On closer inspection, a ribbed surface structure can be seen. The stains/plaques are usually only perceived as "cosmetically" disturbing discolorations of the skin. The risk of developing systemic amyloidosis is about 1%.
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ManifestationThis section has been translated automatically.
m:w=1:1 (some studies indicate a slight preference for the female sex); first manifestation in early and middle adulthood,
LocalizationThis section has been translated automatically.
Mainly interscapular, but also on arms and over large areas of the trunk.
Clinical featuresThis section has been translated automatically.
Blurred, 2.0-10 cm large, hyperpigmented, grey-brown or medium-brown, slightly itchy, but also not very symptomatic spots or plaques, which are also large and map-like due to confluence. Scaling is missing. On close inspection a blunt ribbed surface structure of the areas becomes visible. It is not uncommon for the localisation of the lesions to be associated with permanent trauma due to constant, firm brushing of the skin (friction amyloidosis). The relationship to the notalgia paraesthetica is not certain.
In the flexures areal infiltrates of dirty grey-brown colour with signs of lichenification.
HistologyThis section has been translated automatically.
Direct ImmunofluorescenceThis section has been translated automatically.
Amyloid, additional positive reaction with cytokeratin antibodies.
Differential diagnosisThis section has been translated automatically.
TherapyThis section has been translated automatically.
External therapyThis section has been translated automatically.
- Test with glucocorticoids occlusively with ointments/fatty ointments, e.g. 0.1% mometasone (e.g. Ecural ointment/fatty ointment), 0.25% prednicarbate (e.g. Dermatop ointment/fatty ointment). Often only moderately successful. Alternatively: Injection intrafocally with triamcinolone acetonide crystal suspension(e.g. Volon A diluted 1:2-1:3 with local anaesthetics such as scandicain). Long lasting therapy is necessary.
- If necessary, try therapy with antipruriginosa like Polidocanol shaking mixture R200, the results are also moderate.
- Experimental local DMSO therapy: After thorough cleansing of the affected skin areas apply DMSO 50% R079 once/day. Leads to a cessation of itching, no effect on the amyloid deposits. S.a. Lichen amyloidosus.
Internal therapyThis section has been translated automatically.
Progression/forecastThis section has been translated automatically.
LiteratureThis section has been translated automatically.
- Abels C (2001) Truss-induced macular amyloidosis. dermatologist 52(10 Pt 2): 970 973
- Ahmed I (2001) An unusual presentation of macular amyloidosis. Br J Dermatol 145: 851-852
- Cornejo KM et al (2015) Nodular Amyloidosis Derived From Keratinocytes: An Unusual Type of Primary Localized Cutaneous Nodular Amyloidosis. Am J Dermatopathol 37:e129-133
- Glenner GG (1980) Amyloid deposits and amyloidosis. The beta-fibrilloses (first of two parts). N Engl J Med 302: 1283-1292
- Kaltoft B et al (2013) Primary localised cutaneous amyloidosis--a systematic review. Dan Med J 60:A4727
- Krishna A et al (2012) Study on epidemiology of cutaneous amyloidosis in northern India and effectiveness of dimethylsulphoxide in cutaneous amyloidosis. Indian Dermatol Online J 3:182:186
- Mullins RF (2000) Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB J 14: 835-846
- Özkaya-Bayazit et al (1997) Local DMSO treatment of macular and papular amyloidosis. dermatologist: 48: 31-37
- Palitz LL Peck S (1952) Amyloidosis cutis: a macular variant. Arch Dermatol 65: 451
- Ritter M et al (2003) Localized amyloidosis of the glans penis: a case report and literature review. J Cutan Pathol 30: 37-40
Incoming links (10)Amyloidosis biphasic; Amyloidosis cutaneous special forms; Dmso solution 50% (for external therapy); Dyschromia; Keratinamyloidoses; Notalgia paraesthetica; Polidocanol zinc oxide shaking mixture 3/5 or 10% (nrf 11.66.) [white/skin coloured].; Skin amyloidosis, interscapular; Skin amyloidosis, macular; Vesicular amyloidosis;
Outgoing links (18)Acanthosis; Acitretin; Adverse drug reactions of the skin; Antipruriginosa; Dimethyl sulfoxide; Dmso solution 50% (for external therapy); Glucorticosteroids topical; Hyperpigmentation postinflammatory; Lichen amyloidosis; Lichenification; ... Show all
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