Polidocanol

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Head tincture containing polidocanol; Polidocanol-600-zinc oxide shaking mixture 3/5 or 10 (NRF 11.66.)

Definition
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Polidocanol or Macrogollaurylether is effective as a surface anaesthetic (see also local anaesthetics), antipruriginosum, vein sclerosing agent and belongs chemically to the polyaethylene glycols (PEG).

Pharmacodynamics (Effect)
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Polidocanol belongs to the group of detergent sclerosing agents. Its injection leads to a mixture of sclerosing agent with blood, to endothelial cell lysis and finally to obstruction of the injected vessel.

Indication
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Standard concentration
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  • 3-5% in creams, lotions (see e.g. Optiderm), shaking mixtures and oil baths (antipruriginous effect lasts for about 4 hours)
  • 0.5-3% in injection solutions for vein sclerotherapy

Undesirable effects
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Rare contact allergies.

Recipe(s)
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Head tincture containing polidocanol

Polidocanol zinc oxide shaking mixture 3/5 or 10 % (NRF 11.66.

Polidocanol milk (NFA)

Polidocanol cream 2-5% (The NRF monographs 2 standardized formulations with lauromacrogol 400 in a hydrophobic base, NRF 11.119. and NRF 11.120. The standardized formulations contain a low-water base. The hydrophilic portion is only 20 % (10 % water and 10 % propylene glycol) instead of 70 % as in the hydrophobic base cream DAC).

Preparations
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Thesit, Aethoxysclerol, Recessan, Balneum Hermal plus®, Optiderm®

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Last updated on: 29.10.2020