Colloidmilium juveniles L72.8

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

juvenile colloidal ilium; Juvenile colloid mílium

History
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Woolridge and Frerichs 1960

Definition
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Very rare, probably autosomal recessive inherited disease, which can be pathogenetically distinguished from the adult form of colloidal milium. In this case, there is a focal deposition of colloid as a degradation product of keratinocytes (in contrast to the adult form of colloid milium).

Occurrence/Epidemiology
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Very rare, < 50 cases known in world literature; m:f=1:1;

Etiopathogenesis
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Unknown; familial occurrence is described several times. In contrast to the adult form, the juvenile colloidalmilium is a deposited "keratin colloid" in which gap junctions and desmosomes have been detected by electron microscopy.

Manifestation
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Manifestation prepubertal; beginning of the first changes in the 6th-7th LJ

Localization
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Light-exposed areas of the face (cheeks, perioral, periocular)

Clinical features
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Gradual development of UV-triggered, symptom-free, soft, translucent, yellowish papules and plaques. On pressure, gelatinous material can be expressed from the lesions after incision.

Histology
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Therapy
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Literature
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  1. Alshami MA (2016) Unusual Manifestations of Familial Juvenile Colloid Milium in Two Siblings. Pediatr Dermatol doi: 10.1111/pde.12854.
  2. Chowdhury MM et al (2000) Juvenile colloid milium associated with ligneous conjunctivitis: report of a case and review of the literature. Clin Exp Dermatol 25:138-140
  3. Hashimoto K et al (1989) Juvenile colloid milium. Immunohistochemical and ultrastructural studies. J Cutan Pathol 16:164-174
  4. Martorell-Calatayud A et al (2011) Familial juvenile colloid milium: report of a well documented case. J Am Acad Dermatol 64: 203-206
  5. Oskay T et al (2003) Juvenile colloid milium associated with conjunctival and gingival involvement. J Am Acad Dermatol 49:1185-1188
  6. Schuster V et al (2006) Juvenile colloid milium and ligneous conjunctivitis are caused by severe hypoplasminogenemia--no evidence for causal relationship to non-Hodgkin's lymphoma. J Eur Acad Dermatol Venereol 20:1368.
  7. Woolridge WE et al (1960) Amyloidosis. A new clinical type. Arch Dermatol Syph 82: 230-234

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Last updated on: 29.10.2020