Calcinosis cutis (overview) L94.2

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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calcification of the skin; Calcinosis of the skin; cutaneous calcification; Cutaneous calcinosis

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Deposition of precipitated calcium salts (amorphous calcium phosphate with small amounts of calcium carbonate) in the dermis and subcutis.

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A distinction is made between:

Remark: In the American literature the terms calcinosis metabolica, dystrophica and idiopathica are used synonymously. This seems to be a useful and pragmatic solution from a clinical point of view. Therefore, in this encyclopedia, these terms are listed individually, but are treated under the term "Calcinosis dystrophica".

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Calcium and phosphate ions are present in stable solution in the extracellular fluid. If the solubility point is exceeded, precipitation of hydroxyapatite occurs. Cause: Systemic (metastatic calcinosis) or local, by dystrophic local processes, e.g. alkalization, calcinosis metabolica. In metastatic calcinosis the serum calcium phosphate levels are pathological, in the dystrophic and metabolic form normal.

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More common in systemic scleroderma, for example, see CREST syndrome.

Differential diagnosis
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Oxalosis of the skin

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  2. Deza G et al (2016) Solitary Plaque-type Morphea with Dystrophic Calcinosis Cutis. Acta Derm Venereol 96:418-419
  3. Lai CH et al (2003) Congenital calcinosis cutis of the ear. J Am Acad Dermatol 49: 122-124
  4. Larralde M et al (2003) Calcinosis cutis following liver transplantation in a pediatric patient. Pediatric Dermatol 20: 225-228
  5. Marzano AV et al (1999) Dystrophic calcinosis cutis in subacute lupus. Dermatology 198: 90-92
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  7. Ogretmen Z et al (2002) Calcinosis cutis universalis. J Eur Acad Dermatol Venereol 16: 621-624
  8. Poormoghim H et al (2016) Systemic sclerosis and calcinosis cutis: response to rituximab. J Clin Pharm Ther 41: 94-96
  9. Salmhofer W et al (1995) Cutaneous calciphylaxis in chronic renal failure. Dermatologist 46: 726-731
  10. Zouboulis CC et al (1990) Calcinosis cutis: Cutaneous manifestations of generalized calcinosis in renal hyperparathyroidism. dermatologist 41: 212-217


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Last updated on: 29.10.2020