Aa-type amyloidosis E85.9

Author: Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

Dieser Artikel auf Deutsch


AA-type amyloidosis; systemic amyloidosis

This section has been translated automatically.

Systemic amyloidosis with deposition of amyloid A protein (AA), a fragment of serum amyloid A protein (SAA). One speaks of idiopathic AA amyloidosis in the absence of a recognizable underlying disease.

This section has been translated automatically.

Most common systemic amyloidosis worldwide. Incidence (Central Europe): 1/100.000 inhabitants/year.

This section has been translated automatically.

Clinical features
This section has been translated automatically.

  • Integument: Skin symptoms are generally rather rare. The occurrence of bleeding and alopecia was described by amyloid deposits in the dermis and subcutis.
  • The skin symptoms are accompanied by unspecific general symptoms caused by the primary underlying disease.
  • Extracutaneous manifestation: Cardinal symptom: Progressive renal insufficiency due to amyloid deposits in the basal membrane of the glomerula. Deposits also in the liver, gastrointestinal tract, adrenal glands and CNS.

This section has been translated automatically.

This section has been translated automatically.

Treatment according to the underlying disease and by internists. Use of colchicine in amyloidosis in hereditary Mediterranean fever.

This section has been translated automatically.

  1. Akpolat T et al (2000) Behcet's disease and AA-type amyloidosis. At J Nephrol 20: 68-70
  2. Boorjian S (2002) A rare case of painless gross hematuria: primary localized AA-type amyloidosis of the urinary bladder. Urology 59: 137
  3. Cohen AS, Jones LA (1991) Amyloidosis. Curr Opin Rheumatol 3: 125-138
  4. Cohen AS, Jones LA (1993) Advances in Amyloidosis. Curr Opin Rheumatol 5: 62-76
  5. Csikos M et al (2003) Dystrophic epidermolysis bullosa complicated by cutaneous squamous cell carcinoma and pulmonary and renal amyloidosis. Clin Exp Dermatol 28: 163-166
  6. Escriba A et al (2000) Secondary (AA-type) amyloidosis in patients with polymyalgia rheumatica. At J Kidney Dis 35: 137-140
  7. Hazenberg BP et al (2007) Diagnostic performance of amyloid A protein quantification in fat tissue of patients with clinical AA amyloidosis. Amyloid 14: 133-140
  8. Komatsuda A et al (2003) Amyloid A-type renal amyloidosis in a patient with sarcoidosis: report of a case and review of the literature. Clin Nephrol 60: 284-288
  9. Lubarsch O (1899) Hyaline and amyloid degeneration. Erg allg Path 4: 449-460
  10. Picken MM (2007) New insights into systemic amyloidosis: the importance of diagnosis of specific type. Curr Opin Nephrol Hypertens 16: 196-203
  11. Ruzicka T et al (1990) Cutaneous amyloidosis. Dermatologist 41: 245-255
  12. Virchow R (1854) On the course of amyloid degeneration. Virch Arch 8: 364-368


Please ask your physician for a reliable diagnosis. This website is only meant as a reference.


Last updated on: 29.10.2020