Fludrocortisone

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Synthetic mineralocorticoid.

Half-life
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1 h or 4,8 h (metabolites).

Indication
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Adrenogenital syndrome, Addison's disease, adrenocortical insufficiency.

Limited indication
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Pregnancy, heart failure.

Dosage and method of use
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0.05-0.2 mg/day, simultaneously glucocorticoid substitution adapted to the daily rhythm, e.g. 15-30 mg hydrocortisone.

Undesirable effects
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Systemic application: headache, dizziness, edema, heart failure, metabolic alkalosis, hypokalemia, sodium retention, arthralgias, allergic skin reactions.

Interactions
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Laxatives, saluretics and thiazide diuretics lead to increased hypokalemia.

Contraindication
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Advanced atherosclerosis, hypertension.

Preparations
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Astonin-H

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Last updated on: 29.10.2020