Half-lifeThis section has been translated automatically.
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IndicationThis section has been translated automatically.
As an immunosuppressive agent for therapy-refractory autoimmune diseases such as.
- Systemic Lupus Erythematodes (SLE)
- progressive scleroderma
- Dermatomyositis (MDA5 pos.)
- Vasculitides like granulomatosis with polyangiitis
- Rheumatoid Arthritis
- conditioning treatment before stem cell transplantation and immunotherapy
- Mobilisation of stem cells for stem cell apheresis
Remember! In no way is cyclophosphamide an immunosuppressive agent of first choice in the treatment of collagenosis. It should only be used after failure or when other immunosuppressive drugs are contraindicated!
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As immunosuppressive agent 50-100 mg/day p.o. or pulse therapy with 500-1000 mg i.v. every 2-4 weeks under bladder protection with mesna (20% of the cyclophosphamide dose at 0, 4 and 8 hours after cyclophosphamide administration is recommended). Restricted kidney function requires a dose reduction.
Notice! Before therapy: BB and check kidney and liver function!
Undesirable effectsThis section has been translated automatically.
Cutaneous ADR: Very often urticarial exanthema, reversible alopecia, hyper- or hypopigmentation especially on palms, fingernails and soles.
Haematological ADRs: BB changes (max. day 9-12, recovery on day 15); lymphomas (secondary tumors), leukemia
Gastroenterological ADR: gastrointestinal disorders, hepatitis, gallbladder carcinoma,
UrologicalUAW: cystitis, bladder fibrosis,
Other ADRs: headache, stomatitis, pulmonary fibrosis, azoospermia, anovulation
Remember! Male patients: Before starting therapy and after the end of therapy a spermiogram should be taken. Draw attention to the possibility of cryopreservation of sperm! Risk of permanent damage to the gonads!
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LiteratureThis section has been translated automatically.
- Grunewald S et al (2007) Systemic dermatological treatment with relevance for male fertility. J Dtsch Dermatol Ges 5: 15-21