Amyloidosis (overview) E85.9/L99.0

Heterogeneous group of diseases whose common feature is the extracellular deposition of a "waste protein", the amyloid, which cannot be utilized by the organism.

A distinction is made between cutaneous and systemic amyloidoses. In systemic amyloidoses, a distinction is also made between primary and secondary (concomitant) amyloidoses, and between acquired and hereditary amyloidoses (see also amyloidosis, systemic):

• Localized primarily cutaneous amyloidosis (symptoms at the site of synthesis):
  • Primary cutaneous amyloidosis:
    • Macular cutaneous amyloidosis
    • Papular cutaneous amyloidosis (Lichen amyloidosus)
    • Biphasic cutaneous amyloidosis
    • Nodular cutaneous amyloidosis(Amyloidosis cutis nodularis atrophicans)
    • Amyloidosis cutaneous/special forms.
• Systemic amyloidoses (rare, only minor dermatological relevance):
  • Amyloidosis, hereditary (very rare, no dermatological relevance)
  • Amyloidosis, acquired
    • Amyloidosis of the AL or AH type:
      • Gammopathy-associated amyloidosis
      • Myeloma-associated amyloidosis.
    • Amyloidosis of the AA type (serum amyloid A):
      • Amyloidosis in chronic inflammation
    • amyloidosis-ß2 microglobulin
      • (amyloidosis in long-term dialysis).
    • Amyloidosis TTR (ATTR)
      • (transthyretin amyloidosis)

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