Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Amyloid A, abbreviated as "AA" (AA=amyloid associated) belongs to a group of polymorphic fibre proteins which, in acquired or hereditary amyloidosis, are deposited as insoluble, fibrillar aggregates in organs, vessels and nerves. Amyloidosis is caused by a disturbance in protein folding.

The precursor protein for amyloid A is the serum amyloid A protein (SAA), an acute phase protein. The SAA protein is found in the amyloid after long-term, chronic inflammation (acquired amyloidosis) or in rare hereditary diseases such as familial Mediterranean fever and Muckle-Wells syndrome (AA amyloidosis, urticaria and hearing loss).


Last updated on: 29.10.2020