DefinitionThis section has been translated automatically.
Polyetiologic, chronic inflammatory disease of variable etiology that may be associated with superficial or deep sclerosis of the dermis and/or subcutis, as well as internal organs.
The disease symptoms may show clinical-morphological signs of circumscritic scleroderma or systemic scleroderma, thus mimicking them. The most common case of pseudoscleroderma is indurations in chronic venous insufficiency, CVI .
ClassificationThis section has been translated automatically.
According to etiology, one distinguishes:
- Infectious causes:
- Drug- or toxin-induced:
- Toxic oil syndrome
- Eosinophilic myalgia syndrome (L-tryptophan)
- Epoxy resins
- Pseudoscleroderma due to drugs: phenobarbital, D-penicillamine, gold preparations, hepatitis B vaccine, captopril, spironolactone, allopurinol, bleomycin, doxetaxel, cisplatin, pentazocine, (centrally acting analgesic), cocaine, appetite suppressants
- Foreign material-induced:
- Congestive syndromes:
- Idiopathic- or immunologic-induced:
- Bronchial carcinoma
- Metastatic carcinoid
- Immunocytic lymphoma.
- Physically induced:
- Psychogenically induced:
- See below Psychosomatics.
TherapyThis section has been translated automatically.
LiteratureThis section has been translated automatically.
- Barth J, Kleemann W (1972) Pseudoscleroderma in silicosis. Z Skin Sexkr 47: 123-134
- Behrens S et al (1998) Bleomycin-induced PSS-like pseudoscleroderma. Case report and review of the literature. dermatologist 49: 725-729
- Bretza J, Goldman JA (1979) Scleroderma simulating vinyl chloride disease. J Occup Med 21: 436-438
- Fabris M, Hunzelmann N (2007) Differential diagnosis of scleroderma and psuedoscleroderma. JDDG11:977-984
- Fujii T et al (2003) Pseudoscleroderma associated with transforming growth factor beta1-producing advanced gastric carcinoma: comment on the article by Varga. Arthritis Rheum 48: 1766-1767
- Gray RG, Gottlieb NL (1981) Pseudoscleroderma in hypertrophic osteoarthropathy. JAMA 246: 2062-2063
- Guillet GY et al (1983) Pseudoscleroderma and phenylketonuria. Int J Dermatol 22: 422-426
- Haustein UF (1992) Chemically induced scleroderma. dermatologist 43: 469-474
- Jablonska S (1967) Pseudoscleroderma. Med Small 62: 1151-1154
- Jung AG et al (2010) Unusual chronic scleroderma graft-versus-host disease. dermatologist 61: 514-517
- Pang BK et al (1996) Pseudoscleroderma secondary to phytomenadione (vitamin K1) injections: Texier's disease. Australas J Dermatol 37: 44-47
- Querfeld C et al (2000) Pseudoscleroderma associated with lung cancer: correlation of collagen type I and connective tissue growth factor gene expression. Br J Dermatol 142: 1228-1233
- Roses RM (1992) Localized scleroderma and Borrelia antibody seroconversion. Int J Dermatol 31: 820
- Takagawa S et al (2003) Sustained activation of fibroblast transforming growth factor-beta/Smad signaling in a murine model of scleroderma. J Invest Dermatol 121: 41-50
- Yamamoto T, Nishioka K (2002) Analysis of the effect of halofuginone on bleomycin-induced scleroderma. Rheumatology (Oxford) 41: 594-596
- Yamamoto T et al (2001) Mast cell-independent increase of type I collagen expression in experimental scleroderma induced by bleomycin. Arch Dermatol Res 293: 532-536
- Yamamoto T, Nishioka K (2002) Animal model of sclerotic skin. V: Increased expression of alpha-smooth muscle actin in fibroblastic cells in bleomycin-induced scleroderma. Clin Immunol 102: 77-83
- Yamamoto T, Nishioka K (2003) Role of monocyte chemoattractant protein-1 and its receptor, CCR-2, in the pathogenesis of bleomycin-induced scleroderma. J Invest Dermatol 121: 510-516
- Yamamoto T et al (2002) Analysis of the effect of halofuginone on bleomycin-induced scleroderma. Rheumatology (Oxford) 41: 594-596
Incoming links (7)Bleomycin; Cocaine; Graft-versus-host disease; Polyvinyl chloride disease; Porphyria cutanea tarda; Toxic oil syndrome; Toxic oil syndrome;
Outgoing links (32)Amyloidosis (overview); Bleomycin; Carcinoid syndrome; Chronic venous insufficiency (overview); Circumscripts of scleroderma (overview); Cisplatin; Cocaine; Dermatoliposclerosis; Diabetes mellitus skin changes; Eosinophilic myalgie syndrome; ... Show all
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