HistoryThis section has been translated automatically.
DefinitionThis section has been translated automatically.
Etiologically unexplained, chronic, inflammatory reaction of dermis, subcutis (and fascia) with varying degrees of pain, nodular and plate-like, after proximally sharply defined indurations of the lower legs, channel-like embedded varicose veins(canyon veins) and extensive pigmentation of the skin (S.a. venous diseases)
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EtiopathogenesisThis section has been translated automatically.
Unexplained; many factors indicate that venous hypertension is the decisive pathogenetic principle in CVI ( chronic venous insufficiency). This is supported by the fact that the clinical picture improves with sufficient compression therapy. Dermatoliposclerosis is increasingly observed with Protein S-deficiency and Protein C-deficiency.
ManifestationThis section has been translated automatically.
Predominantly occurring in women of middle to higher age (40-70 years).
LocalizationThis section has been translated automatically.
Distal lower leg (one or both sides).
Clinical featuresThis section has been translated automatically.
Acute dermatoliposclerosis: In the acute phase mostly proximal arc-shaped or tongue-shaped flat erythema; moderate oedematous induration of the distal lower leg with moderate to distinct spontaneous and pressure pain; usually accompanied by oedema of varying extent.
Chronic Dermatoliposclerosis: The chronic stage which follows after months or years shows a pronounced, board-hard dermatosclerosis with extensive brown-red or brown-black discoloration, atrophy of fatty tissue and muscles and miniaturization of the lower leg contour (bottle leg). There is also moderate to marked pain, which increases after physical exertion. In areas with lipodermatosclerosis, cardiac edema typically does not develop. They are found distally and proximally. In particular, skin-coloured, bulging, doughy edema cuffs can develop proximally.
LaboratoryThis section has been translated automatically.
HistologyThis section has been translated automatically.
Intralobular lipomembranous (membranocytic) fat necrosis and pronounced septal sclerosis.
Early lesions show an atrophic epidermis as well as mild lobular necrobiosis with micro- and macropseudo-lipid cysts of varying sizes. Lymphatic infiltrates and hemosiderin deposits in the edematized septa.
In the advanced stage, broad sclerosed septums with bulbous, English wall thickened capillaries and venules with PAS-positive perivascular fibrin sheaths, as well as macrophages and fibroblasts are found. Intralobularly, the fully developed picture of lipomembranous fat necrosis is shown with irregularly large fat or oil cysts which are bounded by thickened, homogeneously eosinophilic and PAS-positive membranes and in places also form papillary vegetation protruding into the lumen. These membranes probably originate from degenerated cell membranes of lipocytes.
Dermal changes: Perivascular superficial and deep sclerosing dermatitis with thickened vessels.
Differential diagnosisThis section has been translated automatically.
- Acute dermatoliposclerosis:
- Erysipelas (acute erysipelas is accompanied by hyperthermia, fever, painful lymphadenitis, leukocytosis and elevation of CRP); in chronic recurrent erysipelas the acute inflammatory symptoms may be absent.
- Erythema nodosum (nodular, highly acute lower leg field dermatosis; localized on the stretching side; painfulness much more pronounced; clear inflammatory parameters).
- Chronic dermatoliposclerosis:
- Circumscript scleroderma (no signs of CVI, atypical localization, usually further scleroderma areas detectable).
- Necrobiosis lipoidica (localization of the lower leg on the extensor side, no signs of CVI, symmetrical infestation in the US would be atypical).
- Erythema induratum (preferably located on the back of the US; size 2.5 cm, rarely up to 10 cm; often deep-reaching painful meltdowns).
Complication(s)This section has been translated automatically.
TherapyThis section has been translated automatically.
Treatment of the underlying chronic venous insufficiency by adequate compression therapy. In addition, acetylsalicylic acid (e.g. ASS) 3 times/day 500 mg p.o. (if necessary 3 times/day 1 g p.o.) until the skin symptoms subside. Systemic glucocorticoids (short-term 5-20 mg prednisone equivalent/day p.o.) are second choice therapeutics.
LiteratureThis section has been translated automatically.
- Bruce AJ et al (2002) Lipodermatosclerosis: review of cases evaluated at Mayo Clinic. J Am Acad Dermatol 46: 187-192
- Huriez C (1955) Ulceres des jambes et troubles trophiques d`origine veineuses. Rev Pract 5: 2703-2721
Kasperczak J et al (2013) Definition, classification and diagnosis of chronic venous insufficiency - part II]. Ginekol Pol 84:51-55
Kucukguven A et al (2013) Matrix metalloproteinases as potential targets in the venous dilation associated with varicose veins. Curr drug targets 14:287-324
- Martin LK et al (2003) Ulcers caused by bullous morphea treated with tissue-engineered skin. Int J Dermatol 42: 402-404
Morton LM et al (2013) Venous eczema and lipodermatosclerosis. Semin Cutan Med Surg 32:169-76
- Naschitz JE et al (1999) Acute lipase-induced panniculitis in rats with ligated veins of the hindlimb: a contribution to the role of acute panniculitis as a precursor of lipodermatosclerosis of venous disease. J Dermatol Sci 19: 9-16
- Stacey MC et al (2000) Pericapillary fibrin deposits and skin hypoxia precede the change of dermatoliposclerosis in limbs at an increased risk of developing a venous ulcer. Cardiovasc Surgery 8: 372-380
Incoming links (17)Callosity of the lower leg; Compression stocking class i; Congestive dermatitis; Edema sclerosis; Livedoid vasculopathy; Livedo racemosa; Livedovasculopathy; Matrix metalloproteinases; Panniculitis nodularis nonsuppurativa; Panniculitis sclerosing; ... Show all
Outgoing links (14)Acetylsalicylic acid; Canyon varices; Chronic venous insufficiency (overview); Circumscripts of scleroderma (overview); Dermatomyositis (overview); Erysipelas; Erythema nodosum; Glucocorticosteroids systemic; Lupus erythematosus profundus; Necrobiosis lipoidica; ... Show all
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