HistoryThis section has been translated automatically.
Pfeiffer 1892; Weber 1925; Christian 1928
DefinitionThis section has been translated automatically.
Increasingly rarediagnosis, when diagnosed accurately, for a focal, non-suppurative (non-suppurative) inflammation of the subcutaneous adipose tissue with fever and formation of symmetrically arranged, reddened, subcutaneous nodules or plaques, occurring in episodes over a period of years.
The classic (Pfeiffer-) Weber-Christian syndrome can be considered as a common pathophysiological final course on different etiological factors. Certainly, the sydnrome is not an independent clinical picture.
To be distinguished are:
- Pancreatic panniculitis (see also under pancreatitis; see also pancreatitis-panniculitis-polyarthritis syndrome).
- Panniculitis in lupus erythematosus
- Panniculitis in alpha-1-antitrypsin deficiency associated panniculitis ( AAT deficiency associated panniculitis).
This contrasts with idiopathic panniculitis without general symptoms.
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EtiopathogenesisThis section has been translated automatically.
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- Nonsteroidal anti-inflammatory drugs such as acetylsalicylic acid (e.g. aspirin; 1.5-2.0 g/day p.o.) or diclofenac (e.g. Voltaren Tbl./Supp.; initial 150 mg, as maintenance dose 100 mg/day).
- In severe clinical pictures with considerable general symptoms glucocorticoids such as prednisone (e.g. Decortin) 80-100 mg/day, creeping out over 3-5 weeks depending on the clinic.
- In severe recurrent disease the following drugs have been tried with varying degrees of success:
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LiteratureThis section has been translated automatically.
- Christian HA (1928) Relapsing febrile nodular nonsuppurative panniculitis. Archives of Internal Medicine, Chicago, 42: 338-351
- Diaz-Cascajo C, Borghi S (2002) Subcutaneous pseudomembranous fat necrosis: new observations. J Cutan catholic 29: 5-10
- Maverakis E et al (2014) Mycobacterium chelonae infection presenting as recurrent cutaneous and subcutaneous nodules--a presentation previously diagnosed as Weber Christian disease. Dermatol Online J 20. pii: 13030/qt9k9535t1
- Pfeifer V (1892) On a case of focal atrophy of the subcutaneous fatty tissue. German Arch Klin Med (Leipzig) 50: 438-44
- Requena L, Sanchez Yus E (2001) Panniculitis. Part II. Mostly lobular panniculitis. J Am Acad Dermatol 45: 325-361
- Riveros Frutos A et al (2014) Nephrotic syndrome in a patient with Pfeifer-Weber-Christian disease. Joint Bone Spine doi: 10.1016/j.jbspin.2014.11.001
- Rotaru N et al (2015) Nonsuppurative Nodular Panniculitis of the Breast. Clin Breast Cancer doi: 10.1016/j.clbc.2015.02.004
- Weber FP (1925) A case of relapsing non-suppurative nodular panniculitis, showing phagocytosis of subcutaneous fat-cells by macrophages. British Journal of Dermatology and Syphilis, Oxford, 37: 301-311
Incoming links (13)Christian weber disease; Granuloma lipophages; Idiopathic nodular panniculitis; Lipogranulomatosis, generalized; Lipogranulomatosis subcutanea; Lipophagic panniculitis of childhood; Mycophenolate mofetil; Panniculitis histiocytic, cytophagic; Panniculitis idiopathic lobular; Panniculitis poststeroidal; ... Show all
Outgoing links (35)Acetylsalicylic acid; Actinomycosis; Acute pancreatitis; Adiposis dolorosa; Borreliosis; Ciclosporin a; Colchicine; Cryptococcosis; Dadps; Dermatoliposclerosis; ... Show all
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