Synonym(s)
HistoryThis section has been translated automatically.
DefinitionThis section has been translated automatically.
Rare disease characterized by spontaneous or pressure painful lipomas, which is mainly observed in obese women in the menopause.
Other symptoms are fatigue, depression and other psychiatric and psychological abnormalities.
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ClassificationThis section has been translated automatically.
Classification of Dercum's disease (n. Hansson E et al. 2012)
- Subtype I Generalized diffuse form
- Subtype II Generalised nodular form
- Subtype III Localized nodular form
- Subtype IV Juxtaarticular form
Occurrence/EpidemiologyThis section has been translated automatically.
m:w=5-30:1 (!) (Bardazzi F et al. 2024)
EtiopathogenesisThis section has been translated automatically.
ManifestationThis section has been translated automatically.
Mostly occurring in obese women during the menopause.
LocalizationThis section has been translated automatically.
ClinicThis section has been translated automatically.
HistologyThis section has been translated automatically.
Normal fat tissue. No inflammatory changes.
Differential diagnosisThis section has been translated automatically.
Painful angiolipomas (increased vascular markings)
Elephantiasis: mainly affects the lower extremities. Limb-shaped swellings; usually only tension pain
Lipoedema: Always symmetrical, disproportionate increase in fat on the arms and legs. Rather a feeling of tension; typically a "caliber jump" to the adjacent healthy region ("muff", "Turkish pants phenomenon", "collar formation"). Hands and feet always remain free
Non-painful lipoma: soft, non-pressurized lump, no spontaneous pain
Lipoedema syndrome, painful: Affects mainly the lower extremity
Multiple symmetrical lipomatosis: Soft non-pressurized lipoma masses, no spontaneous pain
Hematomas of different age and coloration: Characteristic hematoma coloration. remembered trauma
TherapyThis section has been translated automatically.
LiteratureThis section has been translated automatically.
- Bardazzi F et al. (2024)* More than mere lipomas? J Dtsch Dermatol Ges 22:601-603.
- Brodovsky S et al. (1994) Adiposis dolorosa (Dercum's disease): 10-year follow-up. Ann Plast Surg 33: 664-668
- Campen R (2001) Familial occurrence of adiposis dolorosa. J Am Acad Dermatol 44: 132-136
- Dercum FX (1888) A subcutaneous connective tissue dystrophy of the arm and neck, associated with symptoms resembling myxedema. Univ Med Gaz Philadelphia 1: 140-150
- Dercum FX (1892) Three cases of a hitherto unclassified affection resembling in its grosser aspects obesity, but associated with special symptoms: adiposis dolorosa. Am J Med Sci 104: 521-535
- Hansson E et al. (2012) Review of Dercum's disease and proposal of diagnostic criteria, diagnostic
methods, classification and management. Orphanet J Rare Dis 7: 23. - Kyllerman M (2002) Dysarthria, progressive parkinsonian features and symmetric necrosis of putamen in a family with painful lipomas (Dercum disease variant). Neuropediatrics 33: 69-72
- Steiner J (2002) Lipomatosis dolorosa--a frequently overlooked disease picture. Neurologist 73: 183-187
- Wollina U et al. (2018) Differential diagnosis of lipedema and lymphedema. Dermatologist 69:1039-1047
Incoming links (7)
Dercum disease; Lipalgia; Lipedema syndrome, painful; Obesalgia; Obesity dolorosa; Panniculitis nodularis nonsuppurativa; Sacrum syndrome, lipomatous;Outgoing links (8)
Angiolipoma; Elephantiasis; Excision; Lipedema syndrome, painful; Lipoma (overview); Lipomatosis benign symmetric (overview); Liposuction; Pruritus;Disclaimer
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