Lupus erythematosus (overview) L93.-

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 22.03.2023

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Butterfly lichen; Erythematodes; LE; Leloir's disease; Lupus; lupus erythematosus

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The term lupus was used primarily to characterize scarring skin lesions occurring primarily on the face. In 1828, Biett first described the clinical features of lupus erythematosus (LE), and in 1850, his student Cazanave contributed the name "lupus erythematosus." In 1872, Moriz Kaposi mentioned that systemic LE and chronic discoid lupus were one and the same disease. In 1934, O'Leary introduced the classification of LE that is still in use today. This included discoid LE (DLE), usually confined to the skin, acute disseminated LE (usually fatal), and subacute disseminated LE (usually benign).

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Mono- or polytopic, complex autoimmune disease (see also autoantibodies) with a predominantly polygenic disposition characterised by an incorrect elimination of extracellular antigens. This leads to a loss of tolerance and a consecutive pathological immune stimulation with specificity for the body's own antigens.

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Occurrence of autoantibodies in various autoimmune diseases Autoimmune diseases

Disease patterns and common targets of autoantibodies (antigens)
Disease pattern Autoantibodies or antigens
Anti-phospholipid antibody syndrome (APS) Lupus anticoagulant, cardiolipin, ß2-glycoprotein
Graves' disease, M. TSH receptor
Chronic polyarthritis (rheumatoid arthritis) Rheumatoid factor, ANA, histones, ssDNA, fillaggrin
CREST syndrome Centromere (ACA)
Enteritis regionalis (Crohn's disease) ASC
Dermatitis herpetiformis Duhring Endomysium, gliadin, epidermal tissue transglutaminase
Dermatomyositis/Polymyositis PM-Scl, Jo-1, MI2, ssDNA, Ku
Mixed Connective Tissue Disease n-RNP, ss-DNA
Pemphigoid BPAG 1 (BP 230), BPAG 2 (BP 180), Epiligrin
Pemphigus desmoglein 1, desmoglein 3, plakoglobin, STAG
periarteritis nodosa p-ANCA, MPO
Systemic scleroderma or circumstrictive scleroderma SCL-70, ACA
Sjögren's syndrome SS-A, SS-B, rheumatoid factor, salivary gland excretory ducts
Systemic lupus erythematosus (SLE) ds-DNA, ssDNA, Sm antigen, SS-A, SS-B
Drug-induced SLE ss-DNA, Histones
Wegener's granulomatosis c-ANCA, PR3
Sprue, Celiac disease endomysium, gliadin, tissue transglutaminase

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  1. Cazenave PL (1850) Des principales formes du lupus et de son traitement. Gazette of the hôpitaux (Paris) 3 sér. 2: 393
  2. Cazenave PL (1850) Des principales formes du lupus et de son traitement. Gazette of the hôpitaux (Paris) 3 sér. 4: 114
  3. Günther C (2015) Genetics of lupus erythematosus. dermatologist 66: 121-130
  4. Leloir HC (1890) Recherches sur l'histologie pathologique et al nature du lupus érythémateux. Annales de dermatologie et de syphilographie (Paris) 1: 708-709


Please ask your physician for a reliable diagnosis. This website is only meant as a reference.


Last updated on: 22.03.2023