Lupus erythematosus (overview) L93.-

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Butterfly lichen; Erythematodes; LE; Leloir's disease; Lupus; lupus erythematosus

History
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Cazenave, 1850; Leloir 1890

Definition
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Mono- or polytopic, complex autoimmune disease (see also autoantibodies) with a predominantly polygenic disposition characterised by an incorrect elimination of extracellular antigens. This leads to a loss of tolerance and a consecutive pathological immune stimulation with specificity for the body's own antigens.

Classification
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Laboratory
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Occurrence of autoantibodies in various Autoimmune diseases

Disease patterns and frequent targets of autoantibodies (antigens)
Clinical picture Autoantibodies or antigens
Anti-Phospholipid antibody syndrome (APS) Lupus anticoagulant, cardiolipin, ß2-glycoprotein
Graves, M. TSH receptor
Chronic polyarthritis (rheumatoid arthritis) rheumatoid factor, ANA, histones, ssDNA, fillaggrin
CREST syndrome centromere (ACA)
Enteritis regionalis (M. Crohn) ASC
Dermatitis herpetiformis Duhring Endomysium, gliadin, epidermal tissue transglutaminase
dermatomyositis/polymyositis PM-Scl, Jo-1, MI2, ssDNS, Ku
Mixed Connective Tissue Disease n-RNP, ss-DNA
Pemphigoid BPAG 1 (BP 230), BPAG 2 (BP 180), Epiligrin
Pemphigus Desmoglein 1, desmoglein 3, plakoglobin, STAG
periarteritis nodosa p-ANCA, MPO
Systemic scleroderma or circumscribed scleroderma SCL-70, ACA
Sjögren's Syndrome SS-A, SS-B, rheumatoid factor, salivary gland ducts
Systemic lupus erythematosus (SLE) ds-DNA, ssDNA, Sm antigen, SS-A, SS-B
Drug-induced SLE ss-DNA, histones
Wegener's granulomatosis c-ANCA, PR3
Coeliac condition Endomysium, gliadin, tissue transglutaminase

Literature
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  1. Cazenave PL (1850) Des principales formes du lupus et de son traitement. Gazette of the hôpitaux (Paris) 3 sér. 2: 393
  2. Cazenave PL (1850) Des principales formes du lupus et de son traitement. Gazette of the hôpitaux (Paris) 3 sér. 4: 114
  3. Günther C (2015) Genetics of lupus erythematosus. dermatologist 66: 121-130
  4. Leloir HC (1890) Recherches sur l'histologie pathologique et al nature du lupus érythémateux. Annales de dermatologie et de syphilographie (Paris) 1: 708-709

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020