HistoryThis section has been translated automatically.
DefinitionThis section has been translated automatically.
Rare special form of lupus erythematosus integumentalis (about 2-3% of the cases) with painful, inflammatory reddened nodes reaching into the subcutis without significant epidermal involvement. Healing with formation of retracted scars. Combinations with lupus erythematosus chronicus discoides (about 30% of cases) or, less frequently, with systemic lupus erythematosus are possible.
Remark: The clinical picture is probably identical with the"Lymphocytic infiltration of the skin" described by Jessner and Kanof.
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ManifestationThis section has been translated automatically.
Occurs several years before a manifest lupus erythematosus. Predominantly occurring in adults between the ages of 20 and 60; women are affected 2-4 times more frequently than men.
LocalizationThis section has been translated automatically.
Mostly face, buttocks, thighs.
Clinical featuresThis section has been translated automatically.
Usually several, often symmetrically localized, firm, sharply defined mostly symptom-free, subcutaneous nodules or plaques. The overlying skin is discrete red or brown-red and may be slightly bsi clearly retracted. An epidermal involvement is usually absent.
Isolated slight atrophy with delicate scaling.
Healing occurs with dents of varying depth. The disease tends to be intermittent chronic. The overlying epidermis occasionally shows pigmentary shifts.
HistologyThis section has been translated automatically.
Differential diagnosisThis section has been translated automatically.
Malignant lymphomas: Histological exclusion
Panniculitis: exclusion by histological or serological phenomena of lupus erythematosus.
Acne conglobata: exclusion due to the absence of typical acne phenomena (seborrhea, comedones, acne history)
Syphilitic gums (very rare today; see Syphilis acquisita below): exclusion due to negative syphilis serology.
Complication(s)This section has been translated automatically.
TherapyThis section has been translated automatically.
Local glucocorticoids under occlusion; in case of localized process also intralesional application of triamcinolone, if necessary. In addition, continuous therapy with antimalarials ( chloroquine) in a dosage of 1-2 times/day 200 mg p.o. Good long-term effects with cyclophosphamide have been reported. There are some positive reports about the use of Infliximab.
Progression/forecastThis section has been translated automatically.
Systemic lupus erythematosus develops in about 30-35% of patients.
LiteratureThis section has been translated automatically.
- Diaz-Cascajo C, Borghi S (2002) Subcutaneous pseudomembranous fat necrosis: new observations. J Cutan catholic 29: 5-10
- Grossberg E et al (2001) Lupus profundus: not a benign disease. Lupus 10: 514-516
- Günther C et al (2011) Infliximab treatment of a patient with lupus erythematosus profundus. Abstract CD 46th DDG meeting: P16/13
- Hebra F, Kaposi M (1875) On Diseases of the Skin, Including Exanthema. New Sydenham Society, London, 4:1-247
- Irgang S (1940) Lupus erythematosus profundus: report of example with clinical resemblance to Darrier-Roussy sarcoid.Archives of Dermatology and Syphilology, Chicago, 42: 97-108
- Kaposi M (1883) Pathology and therapy of skin diseases. 2nd edition, Urban & Schwarzenberg, S. 642
- Ng PP, Tan SH, Tan T (2002) Lupus erythematosus panniculitis:a clinicopathologic study. Int J Dermatol 41: 488-490
- Wätzig V et al (1989) Lupus panniculitis (Lupus erythematodes profundus). Act Dermatol 15: 109-111
- Wimmershoff MB et al (2003) Discoid lupus erythematosus and lupus profundus in childhood: a report of two cases. Pediatric dermatol 20: 140-145
Incoming links (10)Cold panniculitis; Dermatoliposclerosis; Lep; Leucocytoclasia; Lupus erythematodes chronicus discoides; Lupus erythematosus hypertrophicus et profundus; Lupus erythematosus panniculitis; Lupus erythematosus tumidus; Lupus paniculitis; Panniculitis lupus erythematosus panniculitis;
Outgoing links (12)Acne conglobata; Chloroquine; Cutaneous lupus erythematosus (overview); Early syphilis; Glucorticosteroids topical; Infliximab; Lupus erythematodes chronicus discoides; Lupus erythematosus systemic; Lymphocytic infiltration of the skin; Panniculitis (overview); ... Show all
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