Synonym(s)
TOS; toxic oil syndrome
DefinitionThis section has been translated automatically.
Disease caused by poisoned edible oil with a phase-like course and great clinical similarity to chronic autoimmune diseases of the vascular connective tissue.
Occurrence/EpidemiologyThis section has been translated automatically.
Epidemic 1981 in Spain.
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EtiopathogenesisThis section has been translated automatically.
Consumption of rapeseed oil denatured with aniline.
ManifestationThis section has been translated automatically.
- Acute phase: Women and men are equally affected.
- Chronic phase: Women are affected 6 to 10 times more frequently than men.
Clinical featuresThis section has been translated automatically.
- Acute phase: 7-10 days after consumption fever, dyspnoea due to interstitial pneumonia and pulmonary oedema, gastrointestinal problems.
- Subacute phase: After about 2 months, non-specific pruriginous skin changes, maculopapular or urticarial erythema, arthralgia, myalgia.
- Chronic phase: From the 4th month, in 10-15% of patients neuromuscular syndrome with scleroderma-like or poikilodermatic skin symptoms. Livedo reticularis, Raynaud's syndrome, Sjögren's syndrome, carpal tunnel syndrome, dysphagia or pulmonary hypertension may also occur.
LaboratoryThis section has been translated automatically.
Eosinophilia. IgE elevation. ANA positive 35-80% of the time.
Differential diagnosisThis section has been translated automatically.
TherapyThis section has been translated automatically.
- Symptomatic physical and external therapy (see also scleroderma, progressive systemic), causal therapy unknown. In case of exclusive presence of sclerotic skin changes (without systemic involvement) phototherapy with UVA1 (20 J/cm2, over 6-8 weeks, 4 times/week) or PUVA bath therapy.
- In case of systemic involvement procedure as for progressive systemic scleroderma.
Progression/forecastThis section has been translated automatically.
Chronic stage: Progression over years. In the acute stage death by pulmonary complications.
LiteratureThis section has been translated automatically.
- Bell S et al (1992) The toxic oil syndrome - an example of an exogenously induced autoimmune disease. dermatologist 43: 339-343
- Sanchez-Porro Valades P et al (2003) Toxic oil syndrome: survival in the whole cohort between 1981 and 1995 J Clin Epidemiol 56: 701-708
- Hubbard V et al (2003) Scleromyxoedema-like changes in four renal dialysis patients. Br J Dermatol 148: 563-568
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Outgoing links (8)
Eosinophilic myalgie syndrome; Erythema; Livedo reticularis; Pseudoscleroderma; Puva bath therapy; Scleroderma (overview); Scleroderma systemic; Sjögren's syndrome;Disclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer