Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 18.12.2020

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liquid emulsion; Lotions; Oil-in-water emulsions

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The term "lotion" or lotion is misleading as it is used in cosmetic linguistic usage for a liquid emulsion (e.g. body lotion), i.e. for an O/W emulsion "ointment" (better cream) with a very high water content (see below Ungt. emulsificans aquosum). Both anionic and non-ionic emulsifiers or complex emulsifiers may be included. Just as with hydrophilic creams, preservation is required.

The term lotio (e.g. Lotio alba aquosa) is documented in the medical-pharmaceutical nomenclature in the actual sense for a shaking mixture. However, it is recommended to use the unique term shaking mixture for liquid suspensions.

Pharmacodynamics (Effect)
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Cooling effect. The liquid consistency makes lotions easier to apply than creams to certain areas of the skin, such as hairy or intertriginous areas or hard-to-reach areas.

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Ash Base Lotio, Excipial U Hydrolotio, Lipoderm Lotion, La Roche-Posay Hydranorme W/O Emulsion.

The NRF lists a standardised formulation with the"hydrophilic base emulsion (NRFS.25.)".

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Incompatibility with salicylic acid in lotions containing polyacrylic gel (e.g. Ash Base Lotio): The use of polyacrylate gels in lotions is a popular trick to achieve an optimal smooth consistency of a lotion without increasing the fat component.

The polyacrylate gel has its optimum stability at pH 6-8. Salicylic acid, as the stronger acid (pH 2.4), will release the weaker polyacrylic acid from the polyacrylate. This causes the gel structure to collapse spontaneously, recognisable by a spontaneous liquefaction of the lotion up to the consistency of a drinking milk.

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  1. Wolf G (2012) Inhomogeneities in individual formulations. dermatologist 63: 518-519

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Compatibility of drugs in hydrophilic lotions

Acridine flavinium chloride 2%

Dexpanthenol 5%

Sodium chloride 10

allantoin 0,5%

Dimetine maleate 1%

neomycin sulfate 0,5%.

aluminium chloride 10%

Dimeticone 10%

Nicotinic acid benzyl ester 3%.

Ammonium bituminosulphonate 10

Diphenhydramine HCl 2%

nitrofurazone 0,2%

Amphotericin B 3%

Erythromycin 2%

Nystatin 100 000 IU/g

anthrarobin 2%

Ethacridine lactate 1%

Oleum Pini 1,5

azulene 0,2%

Eucalyptol 10%

Pheniramine hydrogen maleate 1,25%

bacitracin 500 IU/g

Gentamicin sulphate 0,2

Polyvidon iodine 10%

Bamipine HCl 2%

Urea 10% Urea

Prednisolone 0,5% Prednisolone

Benzocaine 10%

Hydrarg. sulf. rubr. 1%

Procaine HCl 2%

Benzoyl peroxide 5%

hydrocortisone 1%

Sulphur 5%

betamethasone-17-valerate 0,1%

hydroxyquinoline sulfate 0,5%.

Sorbic acid 0,1% of

Bufexamac 5%

potassium iodide 3,5%.

Sulphadiazine 5%

calcium chloride 5%

Camphor 5%

sulfisomidine 5%

Chloramphenicol 1%

Cod liver oil 10%

terpiniol 1,5

Chlorophenoxamine-HCl 1,5% Chlorophenoxamine-HCl 1,5% Chlorophenoxamine

Liq. alum. acet. 20%

Tinctura Myrrh 3%

Chlortetracycline HCl 3%

Liq. carb. deterg. 10%

tretinoin 0.1%

Chrysarobin 5%

Menthol 5%

triamcinolone acetonide 0,1

Clioquinol 5%

Merbromine 2%

Undecylenic acid 5%

clotrimazole 1%

Methyl salicylate 5%

Zinc oxide 10

dexamethasone 0,1%

Lactic acid 5

Zinc undecylenate 5%


Last updated on: 18.12.2020