Intestinal diseases, skin changes

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.05.2022

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Definition
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Monitored symptoms and diseases of the skin and skin appendages may indicate cutaneous-intestinal diseases. In most cases they are not specific. In any case, however, they should be the reason for a thorough internal examination initiated by the dermatologist.

Classification
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Pathophysiology
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IL-10 attenuates intestinal inflammation and is a good candidate gene for IBD. Polymorphisms in the IL-10 receptor are also associated with ulcerative colitis, which occurs in early childhood. In addition, severe infantile enterocolitis similar to Crohn's disease is caused by LOF mutations in interleukin-10 and interleukin-10 receptor . The disease is associated with severe perianal abscesses and fistulas. In addition, patients may suffer from recurrent fever and respiratory infections. Cutaneous folliculitis and arthritis also occur in individuals with IL-10 receptor mutations. Hematopoietic stem cell transplantation is currently the only curative therapy.

Therapy
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See the respective diseases in Table 1.

Literature
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  1. Borelli S (2002) Skin manifestations of diseases of the gastrointestinal tract. Schweiz Rundsch Med Prax 91: 1029-1036
  2. Engelhardt KR et al (2014) IL-10 in humans: lessons from the gut, IL-10/IL-10 receptor deficiencies, and IL-10 polymorphisms. Curr Top Microbiol Immunol 380:1-18.
  3. Kirsch B et al (1992) Dermatoses in inflammatory bowel disease. Akt Dermatol 18: 17-22
  4. Mandraka F et al (2003) Cholestasis and vomiting: unusual differential diagnosis in a case of Peutz-Jeghers syndrome. Dtsch Med Wochenschr 128: 984-988
  5. Marks J (1983) Skin diseases and the small intestine. Internist 24: 550-555
  6. Pierer M et al (2002) Extra-intestinal manifestations of chronic inflammatory bowel diseases. Z Gastroenterol 40 (Suppl 1): S92-S104
  7. Trueb RM (2003) Cutaneous manifestations of internal diseases: purpura, livedo, pyoderma gangrenosum. Schweiz Rundsch Med Prax 92: 1479-1487
  8. Ochsendorf F (2020) Manifestations of internal diseases on the skin. Consilium Dermatologie live 2: 24-29.

Incoming links (2)

Autoimmune diseases; Dermadrome;

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Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.05.2022