Pellagra E52

Author: Prof. Dr. med. Peter Altmeyer

Our authors

Last updated on: 29.10.2020

Dieser Artikel auf Deutsch


vitamin B3 deficiency; Vitamin B3 deficiency; Vitamin B3 Hypovitminosis; vitamin B6 deficiency

This section has been translated automatically.

Casál, 1762

This section has been translated automatically.

Rare avitaminosis due to lack of vitamin B3 and possibly other factors of the B-complex (vitamin B6) with skin, intestinal and CNS disorders. Pellagra occurs when the diet consists mainly of maize or sorghum millet. The bound form of niacin (niacytin) present there cannot be utilised by the body. Thus, the disease was widespread in poor regions of Southern Europe and America before the connections were known. Vitamin B3 is mainly found in meat, fish, milk, eggs, rice and minerals. The daily requirement of vitamin B3 is 5-20mg.

This section has been translated automatically.

Endemic in preferred maize diets, especially in Italy, the Balkans, southern states of the USA, Mexico.

In cases of malnutrition (alcoholism), absorption disorders and permanent use of medication ( isoniazid, hydantoins, azathioprine, etc.).

This section has been translated automatically.

In older writings the maximum of the disease is given between the age of 30 and 50.

Time of the manifestations (time of the vernal equinoxes) about the end of March.

In Europe, vitamin B3/B6 deficiencies are more likely to occur in people aged >50 years

This section has been translated automatically.

Especially uncovered (UV-irradiated) parts of the body: back of fingers and hands, shin, face, chest, neck, neck (S.a. Casal's collar).

Clinical features
This section has been translated automatically.

  • Acute "photoprovoked" dermatitis, combined with changes in the intestinal tract and nervous system, characterized by 4 "D": diarrhea, dermatitis, dementia, death.
  • Notice! Often the internal or neurological symptoms are at the forefront of the disease!

  • Skin symptoms: Mostly symmetrical, large-area (5.0-10.0 cm), sharply defined, initially red, later reddish-brown, spots that turn into plaques and fine-lamellar scaling. Blistering or gangrenous ulcerations are possible but rather rare. Typical is the seasonal nature of the disease! Triggered by sunlight and mechanical stress. In case of longer duration: thickening of the skin, painful fissures or rhagades, diffuse palmareratoses.
  • Typical (if not treated) is a recurrent course of symptoms with increasing atrophy of the lesional skin.
  • A generalized livedo reticularis has also been described
  • Mucous membrane changes: Stomatitis, glossitis, vulvitis, dry, chapped, reddened lips. Severe sialorrhea.
  • Gastrointestinal problems: abdominal pain, nausea, vomiting, diarrhoea, in 50% of cases reduced hydrochloric acid production in the stomach.
  • Neurological phenomena: depression, apathy, peripheral polyneuritis, myelitis, psychosis.
  • Pellagroid, pyridoxine deficiency, pernicious anemia, avitaminosis-folic acid, pantothenic acid deficiency.

This section has been translated automatically.

Measurement of the vitamin B3 level (methyl nicotinamide) in urine (using HPLC = high pressure liquid chromatography)

  • Standard value: 1600-4300ug/gCratinine
  • Malnourished: 500ug/g creatinine (pellagra)

Differential diagnosis
This section has been translated automatically.

The most important differential diagnosis is a phototoxic or photoallergic dermatitis! Skin changes occur mainly in the area of the exposed areas! Time of manifestations. Here the neurological conspicuity is missing


  • Photoxic dermatitis: medical history, no diarrhea, no neurological changes
  • Polymorphic light dermatosis: variable course with known pattern, no diarrhoea, no neurological changes, no hyperpigmentation
  • Porphyria cutanea tarda: blister formation after banal mechanical irritation, dark urine! Hepatopathy
  • Porphyria variegata: erythema, blisters, colicky abdominal pain, porphyrin detection in stool and urine
  • Drug reactions: anamnesis, clinical course
  • Acrodermatitis enteropathica: acral localization of the eczematous changes; no sunlight-exposed areas, no hyperpigmentation
  • Kwashiorkor: generalized edema, protein deficiency, thin light hair

This section has been translated automatically.

Nicotinamide (e.g. Nicobion Tbl.) in therapeutic dosage, e.g. 100-300 mg/day p.o. Intravenous substitution only in very severe cases (50-250 mg/day), high protein diet. As prophylaxis: 15-30 mg/day p.o.

This section has been translated automatically.

Name: derived from "Pelle agra" (= rough skin).

This section has been translated automatically.

  1. Badawy AA (2014) Pellagra and alcoholism: a biochemical perspective. Alcohol Alcohol 49: 238-250

  2. Hegyi J et al (2004) Pellagra: dermatitis, dementia, and diarrhea. Int J Dermatol 43: 1-5

  3. Hendricks WM (1991) Pellagra and pellagralike dermatoses: etiology, differential diagnosis, dermatopathology and treatment. Semin Dermatol 10: 282-292
  4. Karthikeyan K et al (2002) Pellagra and skin. Int J Dermatol 41: 476-481
  5. Major RH (1944) Don Gasper Casal, Francois Thiery and pellagra. Bull Hist Med 16: 351-361
  6. Monday A (2016) Pellagra yesterday and today - On the trail of a mystery of the century. Nude Dermatol 42: 131-138
  7. Pfeiffer RF (2014) Neurologic manifestations of malabsorption syndromes. Hand Clin Neurol 120:621-632


Please ask your physician for a reliable diagnosis. This website is only meant as a reference.


Last updated on: 29.10.2020