DefinitionThis section has been translated automatically.
ClassificationThis section has been translated automatically.
Skin symptoms that can occur in case of end-stage renal failure:
- Generalized pruritus (nephrogenic or uremic pruritus)
- elastosis actinica
- Dry scaly skin (xerosis)
- Decrease of sebum and sweat gland secretion
- Increase in the vulnerability of the skin, wound healing disorders.
- Light brownish skin and mucous membrane pigmentation
- Local or diffuse hyperpigmentation.
- disorders of collagen metabolism:
- Reactive, perforating collagenosis
- Hyperkeratosis follicularis et parafollicularis in cutem penetrans (M. Kyrle)
- Folliculitis, perforating
- Carpal tunnel syndrome, Dupuytren's contracture
- Fibrosis of the skin, subcutis and muscles
- Nephrogenic systemic fibrosis
- others, skin diseases:
You might also be interested in
Occurrence/EpidemiologyThis section has been translated automatically.
50-100% of all patients with chronic renal insufficiency suffer from uremic skin changes. In Germany, about 57,000 patients are currently dependent on dialysis. Their number is rising. In uremic skin conditions, the dryness of the integument with ichthyosiform changes and often a permanent pruritus of varying severity are the main symptoms.
Clinical featuresThis section has been translated automatically.
TherapyThis section has been translated automatically.
- Dialysis-induced pruritus is extremely distressing and particularly resistant to therapy. In the therapy of uremic pruritus in dialysis-induced terminal renal insufficiency, kidney transplantation has proven particularly effective. After successful transplantation the pruritus usually stops abruptly.
- If a transplantation is not possible at first, UV irradiation (UVB or high-dose UVA1) is the first choice therapy. Capsaicin (0.01-0.5% in a cream base or as a shaking mixture) is helpful at least temporarily in some cases.
- Dry skin can be treated with greasing creams or ointments (e.g. Ungt. emulsif. aq., Neribas fatty ointment, Ash base fatty ointment) and oil baths (e.g. Balneum Hermal oil bath, Oil bath Cordes).
- Antihistamines have only little value.
- Individual reports exist on thalidomide, morphine antagonists such as naltrexone (50 mg/day p.o.) and erythropoietin. S.a. Pruritus, renal.
LiteratureThis section has been translated automatically.
- Altmeyer P et al (1990) Skin diseases. In: Franz HE (Ed.) Blood purification methods. Thieme, Stuttgart New York, S. 297-305
- Altmeyer P et al (1982) Skin changes in long-term dialysis patients. Dermatologist 33: 303-309
- Crawford GH et al (2002) Skin signs of systemic disease: an update. Adv Dermatol 18: 1-27
- Doctoroff A et al (2003) Protracted calciphylaxis, Part I. Cutis 71: 473-475
- Hubbard V et al (2003) Scleromyxoedema-like changes in four renal dialysis patients. Br J Dermatol 148: 563-568
- Knable AL Jr (2002) Cutaneous nephrology. Dermatol Clin 20: 513-521
- Salmhofer W et al (1995) Cutaneous calciphylaxis in chronic renal failure. Dermatologist 46: 726-731
- Tomson C et al (2003) Vascular calcification in chronic renal failure. Nephron Clin Pract 93: 124-130
- Ulrich H et al (2004) Dialysis-associated skin changes. Dermatologist 55: 485-496
Incoming links (10)Beta2-microglobulin; Dermadrome; Dialysis, skin changes; Dyschromia; Elastosis; Phototherapy; Pruritus nephrogenic; Renal diseases skin changes; Renal failure chronic; Renal pruritus;
Outgoing links (18)Actinic elastosis; Calcinosis cutis (overview); Calciphylaxis; Capsaicin; Collagenosis reactive perforating; Dupuytren's contracture; Folliculitis perforating; Half-and-half nails; Hyperkeratosis follicularis et parafollicularis in cutem penetrans; Nephrogenic systemic fibrosis; ... Show all
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.