Leukemias of the skin C95.9

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Leukosis; Myeloblastic leukemia

Definition
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Specific skin infiltrates in various forms of leukaemia.

Classification
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Specific skin infiltrates are found in the following forms:

Etiopathogenesis
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Clonal growths of the leukopoietic, myeloid or lymphatic system.

Clinical features
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Occurrence of dermatological symptoms usually only after clinical diagnosis. Skin symptoms are rarely observed as a primary manifestation of the disease.
  • Lymphatic leukemia (more than 90% B-cell type, approx. 10% T-cell type):
  • Myeloid leukaemia:
    • Specific skin symptoms (relatively rare): plate-like to nodular infiltration of the skin.
    • Non-specific skin lesions: paleness in secondary anaemia, bleeding in the skin and mucous membranes with a tendency to ulcerous-necrotic transformation, especially in acute myeloid leukaemia; generalised pruritus, prurigo simplex subacuta, macular, nodular, figured erythema; erythrosquamous or vesiculobullous eruptions; very rarely universal non-specific erythroderma.
  • Immature, acute leukoses (myelo- or paramyeloblastic leukemia)
    :Thrombopenic purpura, development of necroses with a tendency to disintegrate in the oral cavity, genital and anal area (by accompanying granulocytosis), candidiasisof
    the mucous membranes, gingival hyperplasia, possibly generalized lymph node enlargement.

Diagnosis
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Blood count, sample excision with histology and immunohistology, chromosome analysis (in chronic lymphatic leukemia in approx. 90% Philadelphia chromosome).

Therapy
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Treatment of the underlying disease by haematooncologists. Treatment of skin changes depending on the clinic.

Literature
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  1. Chen VM et al (2003) Extramedullary presentation of acute leukaemia: a case of myeloid/natural killer cell precursor leukaemia. Pathology 35: 325-329
  2. Damian D et al (2003) Demodex infestation in a child with leukaemia: treatment with ivermectin and permethrin. Int J Dermatol 42: 724-726
  3. Hill A, Metry D (2003) Urticarial lesions in a child with acute lymphoblastic leukemia and eosinophilia. Pediatric Dermatol 20: 502-505
  4. Kazakov DV et al (2003) Blastic natural killer-cell lymphoma of the skin associated with myelodysplastic syndrome or myelogenous leukaemia: a coincidence or more? Br J Dermatol 149: 869-876
  5. Katz KA (2003) Disseminated cutaneous granulomatous eruption occurring in the setting of myelodysplasia. Dermatol Online J 9: 22
  6. Levy I et al (2003) Ecthyma gangrenosum caused by disseminated exserohilum in a child with leukemia: a case report and review of the literature. Pediatric Dermatol 20: 495-497
  7. McCollum A et al (2003) Unusual skin lesions in chronic myelomonocytic leukemia. South Med J 96: 681-684
  8. Yagi H et al (2003) Cutaneous type of adult T cell leukemia/lymphoma: a new entity among cutaneous lymphomas. J Dermatol 30: 641-643

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Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020