Synonym(s)
HistoryThis section has been translated automatically.
DefinitionThis section has been translated automatically.
Very rare disease (Omin 149500) characterized by follicular and perifollicular papules with firmly attached horn support, especially on the legs.
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EtiopathogenesisThis section has been translated automatically.
In elderly patients, associations with diabetes mellitus and chronic renal insufficiency have been described, as well as triggering by dialysis. However, these cases are probably attributable to"reactive perforating collagenosis"!
ManifestationThis section has been translated automatically.
First manifestation in childhood or younger adulthood. Gynecotropy(?).
LocalizationThis section has been translated automatically.
Clinical featuresThis section has been translated automatically.
Asymptomatic, isolated, occasionally grouped, follicular, yellowish to brown-red, sometimes swollen horn nodules. Confluence with larger polycyclic, hyperkeratotic plaques is possible. Easily detachable horny cones, which leave a bowl-shaped crater when detached. Healing with superficially pigmented scars. No itching. The Koebner phenomenon is negative.
HistologyThis section has been translated automatically.
Differential diagnosisThis section has been translated automatically.
External therapyThis section has been translated automatically.
Internal therapyThis section has been translated automatically.
A proven effective therapy is not known: an experiment with acitretin (neotigason) can be performed, first for about 6 weeks in high doses of 0.5-1 mg/kg bw/day, then reduction to maintenance dose of 0.25-0.5 mg/kg bw/day. Successful therapy attempts with allopurinol (e.g. Zyloric) are described on the basis of casuistics (level of evidence IV).
Operative therapieThis section has been translated automatically.
Progression/forecastThis section has been translated automatically.
LiteratureThis section has been translated automatically.
- Ataseven A et al (2014) Kyrle's disease. BMJ Case Rep doi: 10.1136/bcr-2013-009905.
- Cunningham MB et al. (1987) Kyrle's disease. J Am Acad Dermatol 16: 117-123
- Detmar M, Ruszczak Z, Imke E et al (1990) Kyrle disease in juvenile diabetes mellitus and chronic renal failure. Z Hautkr 65: 53-61
- Iyoda M et al (2003) Acquired reactive perforating collagenosis in a nondiabetic hemodialysis patient: successful treatment with allopurinol. Am J Kidney Dis 42: E11-13
- Kruger K et al (1999) Acquired reactive perforating dermatosis. Successful treatment with allopurinol in 2 cases. dermatologist 50: 115-120
- Kyrle J (1916) On an unusual case of universal follicular and parafollicular hyperkeratosis (hyperkeratosis follicularis et parafollicularis in cutem penetrans). Arch Derm Syph 123: 466-493
Rallis E et al (2014) Squamous cell carcinoma developed on Kyrle's disease scar. J BUON 19:317-318
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Incoming links (12)
Collagenosis reactive perforating; Dermatosis perforating; Folliculitis perforating; Hyperkeratosis cyrle; Hyperkeratosis penetrans; Keratosis lichenoides chronica; Kyrle's disease; Kyrle syndrome; Renal diseases skin changes; Salicylic acid ointment (w/o); ... Show allOutgoing links (21)
Acitretin; Chronic prurigo; Collagenosis reactive perforating; Cryosurgery; Curettage; Dyskeratosis follicularis; Elastosis perforans serpiginosa; Excision; Granuloma anulare classic type; Lichen planus classic type; ... Show allDisclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer