Urticaria acute spontaneous L50.8

Authors: Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

All authors of this article

Last updated on: 22.12.2020

Dieser Artikel auf Deutsch


Acute spontaneous urticaria; Acute urticaria; Urticaria; urticaria acuta

This section has been translated automatically.

Urticaria that does not last longer than 6 weeks, which heals spontaneously 2-3 weeks after the first appearance in over 90% of all cases.

This section has been translated automatically.

Acute urticaria (combined with angioedema in 50% of cases) occurs once in a lifetime in 20-25% of the population (lifetime prevalence).

This section has been translated automatically.

Polyetiological genesis!

Infections: An association with acute infections can often be demonstrated and is affirmed in most guidelines. The most frequent associations are with viral infections of the upper respiratory tract. Bacterial infections (sinusitis, urinary tract infections, gastrointestinal infections) may also be causative. The best evidence exists for infection with Helicobacter pylori).

Not infrequently, a combination effect of infection and drug intake can occur (especially anti-inflammatory drugs, non-steroidal especially aspirin or antibiotics).

Drugs can have a triggering effect in different ways. Certain drugs (opiates, muscle relaxants, X-ray contrast media, various antibiotics, biologics) can have a triggering effect. Antibiotics, biologics) can induce a direct histamine liveration. Other drugs (non-steroidal anti-inflammatory drugs) induce cysteinyl leukotrienes in the context of analgesic hypersensitivity.

Type I allergies (Acute spontaneous allergic urticaria): As a triggering cause, type I allergies are detectable in adults < 1%; in children (often pre-existing atopic eczema), IgE-mediated acute urticaria (mostly food allergies) is detectable up to 15%. In these cases further diseases of the atopic circle (rhinitis allergica, allergic bronchial asthma, oral allergy syndrome) are known. The causative food allergies (note: these allergies are usually known to the patients) are triggered by egg, cow's milk, peanut, tree nuts, soy, wheat, fish, shellfish (see below food allergens). In Portugal, urticaria (angioedema) to fish nematodes (anisakiasis) has been described (Anisakis simplex is a common parasite of fish and anisakiasis is still common in Japan, where sushi is often made from freshly caught fish; humans are accidental false hosts).

Intolerance reactions (pseudoallergy) due to drugs or to biogenic amines can occasionally be shown to be the cause of acute urticaria.

This section has been translated automatically.

m:w=1:1; young people are most frequently affected, especially children with atopic dermatitis;

Clinical features
This section has been translated automatically.

Acutely occurring, raised, sharply defined, palpable, solitary or confluent, itchy, whitish to red wheals. The size of the efflorescences can be very variable, from pinhead-sized to extensive. Mostly urticae develop within a few minutes after histamine release. Occasionally the orange peel phenomenon can be triggered. The disease heals within a maximum of 6 weeks, usually within 1-2 weeks.

A special clinical form of acute urticaria is the ( histamine-induced) angioedema, which is accompanied by acute swelling of the face, especially the lips and eyelids.

This section has been translated automatically.

S.u. Urticaria.

General therapy
This section has been translated automatically.

Eliminate or avoid a triggering agent (infection, medication, food allergens) as far as possible. Often the causes cannot be determined. The therapy should then be directed towards symptomatic acute therapy.

External therapy
This section has been translated automatically.

Cooling moist compresses on the face (0.9% NaCl solution), anti-itching lotion with the addition of e.g. Polidocanol 2-5% as a finished product (e.g. Optiderm Lotion/Creme), as a formulation (e.g. Polidocanol-Creme 2-5% or R200) or 1% menthol solution.

Alternatively, glucocorticoid-containing creams/emulsions like 0.5-2% hydrocortisone cream or emulsions like R123, R120.

Advice: The frequently used antihistamine-containing gels (e.g. Fenistil, Tavegil, Soventol) show moderate success.

Internal therapy
This section has been translated automatically.

  • Localized form: For itching oral, non-sedative antihistamines such as desloratadine (Aerius) once/day 10 mg p.o. or levocetirizine (Xusal) once/day 5 mg p.o.
  • Generalized form without mucosal involvement: In acute attacks, antihistamines i.v. such as dimetinden (e.g. Fenistil) 1-2 times/day 1 amp. i.v. or clemastine (e.g. Tavegil) 2-4 mg i.v. Later switch to oral non-sedating antihistamine. Glucocorticoids in medium dosages such as prednisolone (e.g. Solu Decortin H) initially 50-100 mg i.v., then gradual dose reduction depending on the clinic. Later switch to an oral preparation such as methylprednisolone (e.g. Urbason) or prednisolone.
  • Generalized form with mucosal involvement and angioedema: volume substitution, glucocorticoids in high doses i.v. like prednisolone (e.g. Solu Decortin H) 250-500 mg, possibly even higher. After clinical findings, repeated administration may be necessary. Gradual dose reduction according to clinical findings 250-150-100-75-50-25 mg and switch to oral preparation such as methylprednisolone (e.g. Urbason).
    Antihistamines initial e.g. Dimetinden (e.g. Fenistil) 4 mg i.v. (conversion to oral medication up to 6 mg/day, reduction according to clinic) or Clemastine (e.g. Tavegil) 2-4 mg.
  • For laryngeal glottis oedema: Additional adrenalin (suprarenin 1:1000) 0.3-0.5 ml s.c., repeated administration also possible. In highly acute cases: after diluting 1 ml of the commercially available epinephrine solution (1:1000) to 10 ml or using a pre-filled epinephrine syringe (1:10,000), 0.5-1.0 ml (= 0.05-0.1 mg epinephrine) is first injected slowly i.v. (0.1 mg/min.) under pulse and blood pressure control.
  • Cave! A maximum dose of 1 mg adrenaline should not be exceeded as a rule.

  • Notice!

    Risk of arrhythmias up to ventricular fibrillation and myocardial ischemia! Oxygen delivery 4-6 liters per minute. Intubation if necessary. Ultima ratio are coniotomy or tracheotomy.
  • Especially in cases of respiratory distress and concomitant obstructive respiratory disease, injection of terbutaline sulphate (e.g. Bricanyl) 0.5-2.0 mg/day i.v. or fenoterol (e.g. Berotec dosage aerosol) once 1 stroke.
  • Generalized form with angioedema and anaphylactic shock: Stage-specific shock therapy.

This section has been translated automatically.

  1. Anliker MD et al (2003) Acute Urticaria and Angioedema due to Ehrlichiosis. Dermatology 207: 417-418
  2. Czarnetzki BM et al (1991) Urticaria, diagnostics and therapy. Dt. Derm. 39: 280-286
  3. Fays S et al (2003) Bupropion and generalized acute urticaria: eight cases. Br J Dermatol 148: 177-178
  4. Flesche CW et al (1996) The anaphylactic shock. dermatologist 47: 650-660
  5. Gauger A et al (2002) Acute edematous ecchymoses in young children. dermatologist 53: 559-560
  6. Grabbe et al (1992) Acute and chronic urticaria. German Med Vschr 117: 1365-1370
  7. Hecker C et al (1991) Urticaria and angioedema. Close to the skin Derm 1: 85-87
  8. Maurer M et al (2003) Relevance of food allergies and intolerance reactions as causes of urticaria. dermatologist 54: 138-143
  9. Monroe EW (1985) Treatment of urticaria. Dermatol Clin 3: 51-55
  10. Zuberbier T (2003) Urticaria. Allergy 58: 1224-1234
  11. Nettis E et al (2003) Clinical and aetiological aspects in urticaria and angio-oedema. Br J Dermatol 148: 501-506
  12. Nigen S et al (2003) Drug eruptions: approaching the diagnosis of drug-induced skin diseases. J Drugs Dermatol 2: 278-299


Please ask your physician for a reliable diagnosis. This website is only meant as a reference.