Results for "psoriasis"

...n be affected. On the other hand, pre-existing cutaneous inflammatory diseases (e.g. lichen planus, psoriasis, sarcoidosis) can be activated or reactivated. As the autoreactive T-cell clones underlying irAEs a...

PSORS12 Definition Psoriasis 12, also known as psoriasis susceptibility 12, is a genetic locus associated with psoriasis. There...

PSORS13 Definition PSORS13 (Psoriasis Susceptibility 13) is a genetic locus associated with psoriasis. PSOS13 is located on chromosome 6q...

...al. It typically appears as early as 1 year of age and clinically exhibits characteristics of both psoriasis and pityriasis rubra pilaris. Erythrodermic courses are not rare. In the classifications of pityria...

...ammatory skin diseases that are accompanied by pustule formation. For example, generalized pustular psoriasis (GPP/Zumbusch type) (Farooq M et al. 2013).Other IL36RN-associated diseases are classified as forms...

...or the IL-36 receptor antagonist, are more common in patients diagnosed with both AGEP and pustular psoriasis than in unaffected individuals (Sidoroff A et al. 2007; Meier-Schiesser B et al. 2019; Navarini AA...

...se III studies (AMAGINE-2 and AMAGINE-3) in more than 1,800 patients with moderate to severe plaque psoriasis showed that 36.7% of patients in the 210 mg brodalumab group, 18.5% in a group with the IL-12/-23 a...

...s if their response to previous disease-modifying, anti-rheumatic drug therapy has been inadequate. Psoriasis vulgaris (moderate to severe plaque-type psoriasis in adults who have not responded to other system...

...apeutic is of interest; a large number of publications are available on this topic. General therapy Psoriasis, spondyloarthritis (Spa) with axial as well as peripheral arthritis, ankylosing spondylitis, psoria...

...M. Behçet, dermatomyositis, sarcoidosis, T-cell lymphomas, pemphigus vulgaris, bullous pemphigoid, psoriasis vulgaris, atopic eczema (most severe forms), lichen planus mucosae (topical application also possib...

...nd are all inherited in an autosomal dominant manner, leading to a loss of melanocytes in the skin. Psoriasis: The integrity of the epidermal melanin unit is also disrupted in psoriasis (Nickoloff BJ 2004). It...

...s or candida infections.Exfoliatio areagta linguae occurs more frequently in patients with pustular psoriasis(Psoriasis pustulosa - Dreyer LN et al. 2012). In this context, the detection of IL36RN gene mutatio...

...s study results in other models of inflammation, such as arthritis, inflammatory bowel disease, and psoriasis confirmed the hypothesis of dual use of the IL-12p40 subunit by interleukins-12 and -23.Interleukin...

...antly influences inflammatory processes is IL-17, which plays a central role in the pathogenesis of psoriasis, psoriatic arthritis and rheumatoid arthritis. As antipsoriatic and/or antirheumatic drugs there ar...

...suppressive and anti-inflammatory effect and is used for the treatment of moderate to severe plaque psoriasis. Spectrum of action Ixekinumab binds with high affinity to interleukin-17A (IL-17A) and inhibits th...

...nclude:AdiponectinC1q/tumor necrosis factor-related protein (CTRP) General information Resistin and psoriasis:In rodents, resistin is mainly produced by the WAT, whereas in humans it is mainly secreted by immu...

...ammatory and selective immunosuppressive effects. Tildrakizumab is used for the treatment of plaque psoriasis. The effects are based on the binding and inactivation of the cytokine interleukin-23 (IL-23). Phar...

...ments on cytotoxic cells, especially NK cells. Indication For moderately severe and severe forms of psoriasis vulgaris that require systemic treatment ( off-label use, not permitted in Europe!). Pregnancy/nurs...

...esterase-4 inhibitor) developed by Celegene for the indications spondylitis, psoriatic arthritis or psoriasis arthropathica, and moderate to severe psoriasis vulgaris (S3 guideline). A small monocentric study...

...® (bimekizumab) was launched on the German market on September 15, 2021 for the treatment of plaque psoriasis . Two anti-IL-17A antibodies, ixekizumab and secukinumab, have already been approved for the treatm...

...phase III studies (CIMPASI-1/-2 as well as CIMPACT), for the treatment of moderate-to-severe plaque psoriasis (Gottlieb AB et al. 2018). In the CIMPACT trial, the PASI 75 at week 12 of therapy under 200mg was...

...ultiforme in the wake of reactivated herpes simplex Pityriasis rosea (classic form) Guttate type of psoriasis vulgaris (in 3% of psoriatic patients, both as a flare-up reaction or as a worsening of the existin...

...pro-inflammatory cytokines.Such mutations are also found in about 80% of sporadic cases of pustular psoriasis without additional manifestations of psoriasis vulgaris. In contrast, IL-36RN gene mutations are on...

...Although the skin changes have a psoriasiform pattern, there is no etiopathogenetic relationship to psoriasis. In rare cases, M. Grover-like manifestations may occur (Hofmann J et al. 2025). Classification Acc...

PSORS15 Definition PSORS15 (PSORS15 stands for: Psoriasis Susceptibility 15) is a genetic locus associated with psoriasis. The gene is located on chromosome...