DefinitionThis section has been translated automatically.
Immunosuppressively active fusion protein (dimer) consisting of an extracellular CD2 binding site of leukocyte functional antigen 3 (LFA-3) and portions of IgG1
Pharmacodynamics (Effect)This section has been translated automatically.
Inhibition of lymphocyte activation by specific binding to CD2 and inhibition of LFA-3/CD2 interaction. Reduction of CD2+ T lymphocytes, especially CD45 RO+ cells, probably by binding of CD2 to target cells and the Fc fragments on cytotoxic cells, especially NK cells.
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IndicationThis section has been translated automatically.
Pregnancy/nursing periodThis section has been translated automatically.
Insufficient data on use in pregnancy and lactation are available. Should not be prescribed during pregnancy and lactation.
Complication(s)This section has been translated automatically.
Lymphocytopenia (dose-dependent, especially with CD4 and CD8 cells)!
Cave! Weekly control of lymphocyte subpopulations, especially CD4 lymphocytes in the differential blood count!
Dosage and method of useThis section has been translated automatically.
Once/week 7.5 mg Alefacept i.v. or once/week 15 mg i.m. for 12 weeks.If necessary, repeat the therapy cycle after a 12-week therapy break.
ContraindicationThis section has been translated automatically.
Lymphocytopenia with planned therapy start.
PreparationsThis section has been translated automatically.
LiteratureThis section has been translated automatically.
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- Gottlieb AB (2003) CD4+ T-cell-directed antibody responses are maintained in patients with psoriasis receiving alefacept: Results of a randomized study. J Am Acad Dermatol 49: 816-825
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- Vaishnaw AK et al (2002) Pharmacokinetics, biologic activity, and tolerability of alefacept by intravenous and intramuscular administration. J Pharmacokinet Pharmacodyn 29: 415-426
- Weinberg JM, Tutrone WD (2003) Biologic therapy for psoriasis: the T-cell-targeted therapies efalizumab and alefacept. Cutis 71: 41-45