Anethole

Authors: Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

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Last updated on: 29.10.2020

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Synonym(s)

Anetholum; CAS No.: 480-23-8; p-Methoxypropenylbenzene

Definition
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Anetholum, p-methoxypropenylbenzene; CAS No.: 480-23-8Anethol
is an organic compound which is highly soluble in ethanol and insoluble in water. It is a component of various essential oils, e.g. anise oil (see below Anisi fructus) and fennel oil. Anethole occurs as trans-anethole and cis-anethole in fennel, anise and star anise. The smell of anethole is responsible for the typical aniseed aroma. A structural isomer of anethole is tarragol.
Anethole has a secretolytic, secretomotoric, antihelmintic and antibacterial effect on different types of aniseed. species. At the same time it shows a spasmolytic effect, which is why it can be used as an expectorant. Experiments have shown an anticarcinogenic effect.
Anethole is used as a fragrance and flavoring agent mainly in hygiene products in soaps and oral care products, but also in food chemistry.

Literature
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  1. de Groot AC et al.(2016) Essential Oils, Part III: Chemical Composition. Dermatitis 27:161-169.
  2. Shahbazian S et al.(2015) Anti-cancer activity of pegylated liposomal trans-anethole on breast cancer cell lines MCF-7 and T47D. Biotechnol Lett 37:1355-1359.
  3. Topuz OK et al (2016) Physical and antimicrobial properties of anise oil loaded nanoemulsions on the survival of foodborne pathogens. Food Chem 203:117-123.
  4. Wakabayashi KA et al (2015) thelmintic effects of the essential oil of fennel (Foeniculum vulgare Mill., Apiaceae) against Schistosoma mansoni. Chem Biodivers 12:1105-1114.
  5. Wisniewski-Rebecca ES et al (2015) Synergistic effects of anethole and ibuprofen in acute inflammatory response. Chem Biol Interact 242:247-253.
  6. Zahid MS et al (2015) Anethole inhibits growth of recently emerged multidrug resistant toxigenic Vibrio cholerae O1 El Tor variant strains in vitro. J Vet Med Sci 77:535-540.

Incoming links (1)

Anisi fructus;