Adonidis herba

Authors: Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

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Last updated on: 04.06.2021

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Synonym(s)

Adonis herb

Definition
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Adonidis herba, also called Adonis herb Adonidis herba is used as a herbal medicine for heart and circulatory complaints. It is obtained from its parent plant Adonis vernalis L. the spring Adonis her b. Note: The medicinal cardiotherapeutic use of Adonidis herba no longer plays a significant role today, as there are much more effective and controllable cardiotherapeutic agents.

Adonis herba has not been processed by the HPMC or the ESCOP.


Commission E: mildly impaired cardiac performance (heart failure NYHA stage I-II), especially with accompanying nervous symptoms.

Due to the content of strongly cardiac cardenolides, which are also responsible for the toxicity of the plant, a classification of Adonis herb as a traditional herbal medicinal product in the sense of § 39a AMG is prohibited.

Ingredients
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Efficacy determining ingredients are: contains the cardenolides adonidoside, adonivernoside, cymarin and the main glycoside adonitoxin (a digitalis-like glycoside). Other ingredients include flavones.

Effects
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Adonidisherba has a central sedative effect; it is also positively inotropic and vein tonifying. In contrast to digitalis, adonis herb has a faster but less lasting effect.

Field of application/use
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Adonis herb is used for slightly restricted cardiac performance (cardiac insufficiency stage I-II), especially with nervous accompanying symptoms. In addition, it is used for functional heart complaints and circulatory instability with nervous accompanying symptoms, which do not yet require digitalization.

Dosage
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Caution: Due to the content of strongly cardiac cardenolides, which are also responsible for the toxicity of the plant, a classification of adonis herb as a traditional herbal medicinal product in the sense of § 39a AMG is prohibited.

The common, average daily dose is 0.6 g of adonis powder. The maximum single dose is 1.0 g, the maximum daily dose is 3.0 g.

Undesirable effects
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Nausea, vomiting, cardiac arrhythmia

Recipe(s)
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Fixed Combination: A fixed combination of Adonidis herba (adonis herb liquid extract), Convallariae herba (lily of the valley herb dry extract), Scillae bulbus (sea onion dry extract) and Oleandri folium (oleander leaf dry extract)

has a negative effect on the excitation conduction of the heart and a positive effect on the stimulation threshold of the heart.

Indications: Fixed combinations of this composition are used in cases of reduced cardiac output with associated circulatory instability.

Contraindications: In case of existing NYHA stage III and IV heart failure, during therapy with digitalis glycosides, potassium deficiency, digitalis intoxication, bradycardia or ventricular tachycardia, it should not be taken.

Adverse effects: In rare cases nausea, vomiting, diarrhea, stomach upset, irregular pulse or cardiac arrhythmia may occur.

Interactions: There may be an increase in effects and side effects if calcium, quinidine, saluretics, laxatives are taken at the same time or in long-term therapy with glucocorticoids.

Dosage:
In adults, the daily dose of solid and single-dose forms is between 270 and 540 MSE, and 3101 MSE for liquid forms.
The extracts are mixed in a ratio of 25: 15: 25: 25.

For liquid dosage forms, the following compositions are produced per 100 ml
: liquid extract of adonis herb 5.99 mg total glycosides (= 5,000 MSE), dry extract of lily of the valley 0.97 mg total glycosides (= 3,125 MSE), dry extract of sea onion 1.73 mg total glycosides (= 5,000 MSE) and dry extract of oleander leaves 0.86 mg total glycosides (= 5,000 MSE).

Trade names
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Finished preparations are not known. Combination preparations of Adonis rose herb+ Lily of the valleyherb (Convalleriae herbae) +Marsh onion(Scillae bulbus) +Oleander leaves(Oleandri folium) are widely used (Miroton solution®). Unless otherwise prescribed, adults and adolescents over 12 years of age take 20 - 30 drops 1 - 3 times daily (max. 60 drops daily).

Note(s)
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Finished medicinal products of the Adonis herb are no longer available on the market today. We also advise against the use of individual formulations, as the plant, which originates from wild stocks, contains different amounts of the active ingredients depending on the location and harvesting time, and a standardization of the substances is therefore not possible.

Literature
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  1. Schlicher H (2016) Leitfaden Phytotherapie, Urban & Fischer Verlag, Munich, p. p46.
  2. https://arzneipflanzenlexikon.info/adonisroeschen.php