Adonidis herba

Authors: Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

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Last updated on: 27.08.2023

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Adonis herb

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Adonidis herba, also called Adonis herb Adonidis herba is used as a herbal medicine for heart and circulatory problems. It is obtained from its parent plant Adonis vernalis L. the spring Adonis her b. Note: The medicinal cardiotherapeutic use of Adonidis herba does not play a significant role today, as there are much more effective and controllable cardiotherapeutics.

Quality specified in the German Pharmacopoeia (DAB) until 2014, quality specification for "Adonis vernalis for homeopathic preparations" in the European Pharmacopoeia.

HMPC: not edited

ESCOP: not edited

Commission E-monograph: slightly impaired cardiac output(heart failure NYHA stage I-II), especially with accompanying nervous symptoms.

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Efficacy determining ingredients are: contains the cardenolides adonidoside, adonivernoside, cymarin and the main glycoside adonitoxin (a digitalis-like glycoside). Other ingredients include flavones.

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Adonidisherba has a central sedative effect; it is also positively inotropic and vein tonifying. In contrast to digitalis, adonis herb has a faster but less lasting effect.

Field of application/use
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Adonis herb is used for slightly restricted cardiac performance (cardiac insufficiency stage I-II), especially with nervous accompanying symptoms. In addition, it is used for functional heart complaints and circulatory instability with nervous accompanying symptoms, which do not yet require digitalization.

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Caution: Due to the content of strongly cardiac cardenolides, which are also responsible for the toxicity of the plant, a classification of adonis herb as a traditional herbal medicinal product in the sense of § 39a AMG is prohibited.

The common, average daily dose is 0.6 g of adonis powder. The maximum single dose is 1.0 g, the maximum daily dose is 3.0 g.

Undesirable effects
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Fixed combination: Afixed combination of Adonidis herba (Adonis herb liquid extract), Convallariae herba (Lily of the Valley dry extract), Scillae bulbus (Sea onion dry extract) and Oleandri folium (Oleander leaf dry extract).

negatively affects the conduction of excitation of the heart and positively affects the threshold of excitation of the heart.

Indications: Fixed combinations of this composition are used in impaired cardiac output with accompanying circulatory lability.

Contraindications: Use should be avoided in existing heart failure of NYHA stages III and IV, during therapy with digitalis glycosides, potassium deficiency, digitalis intoxication, bradycardia, or ventricular tachycardia.

Adverse effects: Nausea, vomiting, diarrhea, stomach discomfort, irregular pulse or cardiac arrhythmia may occur in rare cases.

Druginteractions: In case of simultaneous intake of calcium, quinidine, saluretics, laxatives or in case of long-term therapy with glucocorticoids, the effects and side effects may be increased.

In adults, the daily dose of solid and single-dose dosage forms ranges from 270 to 540 MSE, and 3101 MSE for liquid dosage forms.
The extracts are mixed in a ratio of 25: 15: 25: 25.

For liquid dosage forms, the following compositions are obtained per 100 ml
:adonis herb liquid extract 5.99 mg total glycosides (= 5,000 MSE), lily of the valley herb dry extract 0.97 mg total glycosides (=3.125 MSE), sea onion dry extract 1.73 mg total glycosides (=5,000 MSE) and oleander leaf dry extract 0.86 mg total glycosides (=5,000 MSE).

Trade names
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Finished preparations are not known. Combination preparations of Adonis rose herb+ Lily of the valleyherb (Convalleriae herbae) +Marsh onion(Scillae bulbus) +Oleander leaves(Oleandri folium) are widely used (Miroton solution®). Unless otherwise prescribed, adults and adolescents over 12 years of age take 20 - 30 drops 1 - 3 times daily (max. 60 drops daily).

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Finished medicinal products of the Adonis herb are no longer available on the market today. We also advise against the use of individual formulations, as the plant, which originates from wild stocks, contains different amounts of the active ingredients depending on the location and harvesting time, and a standardization of the substances is therefore not possible.

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  1. Schlicher H (2016) Leitfaden Phytotherapie, Urban & Fischer Verlag, Munich, p. p46.