Synonym(s)
SS-A antibodies; SSA antibody
DefinitionThis section has been translated automatically.
Heterogeneous antibody complex consisting of autoantibodies against a 52 and 60 kDa nuclear protein.
General informationThis section has been translated automatically.
Anti-Ro/SSA is considered a relatively specific autoantibody for various autoimmune diseases, especially:
- Lupus erythematosus, systemic (SLE)
- Lupus erythematosus, subacute cutaneous (SCLE)
- Sjögren's syndrome (SS)
- SLE overlap syndrome.
HLA-DR3 is associated with anti-Ro and anti-La antibodies.
Patients with C2 and C4 deficiencies tend to produce anti-Ro/SSA antibodies without detection of anti-La/SSB antibodies.
Anti-Ro/SSA antibodies are found irregularly in the following diseases:
- polymositis/dermatomyositis
- Non-erosive arthropathy (Jaccoud arthropathy)
- Late-Onset-SLE
- Neonatal lupus erythematosus.
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OccurrenceThis section has been translated automatically.
Detection in 30-40% of cases of systemic lupus erythematosus and 60-70% of cases of Sjögren's syndrome. RO-antibodies are particularly important in neonatal lupus erythematosus in combination with a congenital heart block caused by expression of the FSA antigen in the excitation conduction system. In 70-80% of patients with subacute cutaneous lupus erythematosus, Ro/SS-A antibodies are detectable and simultaneously associated with increased light sensitivity. UV exposure leads to induction of SS-A on keratinocytes.
Note(s)This section has been translated automatically.
RO = Patient initials
LiteratureThis section has been translated automatically.
- Arbuckle MR et al (2003) Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med 349: 1526-1533
- Franceschini F et al (2005) Anti-Ro/SSA and La/SSB abtibodies. Autoimmunity 38: 55-63
- Furukawa F et al (1990) Binding of antibodies to the extractable nuclear antigens SS-A/Ro and SS-B/La is induced on the surface of human keratinocytes by ultraviolet light (UVL): implications for the pathogenesis of photosensitive cutaneous lupus. J Invest Dermatol 94: 77-85
- Ho KT et al (2003) The clinical relevance of autoantibodies in scleroderma. Arthritis Res Ther 5: 80-93
- Popovic K et al (2006) Fine specifity of the Ro/SSa antoantibody response in relation to serological and clinical findings in 96 patients with self-reported cutaneous symptoms induced by the sun. Lupus 16: 10-17
Prof. Dr. med. Peter Altmeyer