Toxic epidermal necrolysis. 2 weeks after taking Allopurinol in recurrent attacks of gout, itching and redness on the back for the first time, within a few days dramatic worsening of the general condition with several acute, flat, generalized, randomly distributed, sharply defined, red, weeping and painful erosions. Additional findings were multiple, acute, asymmetrically arranged, disseminated, skin-coloured blisters on a flat erythema on the remaining integument.
Zoster. 6 days of persistent segmental erosions, partly crusty, on the back of a 66-year-old, very obese female patient. The right axilla showed identical skin lesions.
Toxic epidermal necrolysis. detailed view of a solitary, acutely occurring, perimamillary, sharply defined, slightly weeping, extensive, erosive detachment of the skin. the sample biopsies showed a vacuum-associated interfacial dermatitis with epidermal keratinocyte necroses.
Lymphomatoid papulosis. reflected light microscopy (detail): In the initial phase of a papule eruption a concentric or radial pattern of punctiform or garland-like vascular ectasia is visible. partially brownish background pigment (oxidative haemoglobin degradation).
Acne conglobata: inflammatory, also abscessing nodules, bowl-shaped atrophic scars. continuous course of acne since puberty. the skin symptoms are combined with severe acne inversa of the axillae and inguinal regions.
Collagenosis, reactive perforating. detail enlargement: solitary, 0.3-1.3 cm large, red papules with a coarse central horn plug. the smaller papules correspond to an early stage of the disease.
Acne fulminans: for months, known Acne vulgaris; now for several months intermittent febrile occurrence of rapidly melting, painful pustules Laboratory: inflammation parameters significantly increased, neutrophil leukocytosis (>10.000/ul)
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