Xanthome eruptive E78.2

Author: Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

Dieser Artikel auf Deutsch

Synonym(s)

Eruptive xanthomas; Eruptive xanthomes

Definition
This section has been translated automatically.

Rapidly occurring in large numbers, disseminated over the body, papular yellow xanthomas with an inflammatory yard. Xanthomas are marker lesions for various diseases. Xanthomas are marker lesions for various lipid metabolism disorders, but are not strictly correlated with them.

Etiopathogenesis
This section has been translated automatically.

Associations with hyperlipoproteinemia type IV according to Fredrickson (E78.1) (see also classification according to Fredrickson), chylomicronemic syndrome (E78.3); familial hypertriglyceridemia (E78.1); diabetes, chronic alcohol consumption, nephrotic syndrome, pancreatitis, medication and pregnancy have been described.

Manifestation
This section has been translated automatically.

Children and young people, adults: 20-60 years

Localization
This section has been translated automatically.

Mainly glutaeal region, extremity extensor sides.

Clinical features
This section has been translated automatically.

Within a few weeks exanthematically shooting up, multiple, 0.2-0.3 cm large, disseminated, flat raised, symptomless or slightly itchy, yellow or red, surface smooth, firm, sharply edged nodules. The nodules may aggregate in places, resulting in mulberry-like formations. Linear alignment of the nodules is also possible (Köbner phenomenon).

Complication(s)
This section has been translated automatically.

Acute pancreatitis, diabetes mellitus, reactive cardiovascular diseases

Therapy
This section has been translated automatically.

Cosmetically disturbing xanthomas can be removed surgically, also by laser, curettage or ablation with an electrical sling. If necessary, dabbing with trichloroacetic acid (e.g. as finished drug: Solco Derman or as Rezetpur:trichloroacetic acid solution 10/20/35/50% (NRFl 11.133.)).

General therapy
This section has been translated automatically.

Detection and treatment of the metabolic disorder. First of all, dietetic measures and lifestyle modifications (weight reduction, abstinence from nicotine, increase physical activity) should be taken and, in the absence of improvement, adjustment to lipid reducers should be made.

Internal therapy
This section has been translated automatically.

If a lipid metabolism disorder is detected, dietary measures and adjustment to lipid-lowering drugs such as Acipimox (e.g. Olbemox) 3 times 250 mg/day p.o. or Simvastatin (BeL Simvastatin) initially 5-10 mg p.o. (weekly dose increase up to 40 mg p.o.).

Note(s)
This section has been translated automatically.

The lipoproteins of plasma consist of lipids (triglycerides, fats, cholesterol and phospholipids) and apolipoproteins. Disorders of lipid metabolism are often found together with a metabolic syndrome, obesity, impaired glucose tolerance or insulin resistance, hypertriglyceridemia, reduction of HDL cholesterol and arterial hypertension.

Literature
This section has been translated automatically.

  1. Chang HY et al (2003) Eruptive xanthomas associated with olanzapine use. Arch Dermatol 139: 1045-1048
  2. Digby M et al (2011) Eruptive xanthomas as a cutaneous manifestation of hypertriglyceridemia: a case report. J Clin Aesthet Dermatol 4:44-46

  3. Jaber PW et al (1992) Eruptive xanthomas during pregnancy. J Am Acad Dermatol 27: 300-302
  4. Kala J et al (2012) Images in clinical medicine. Eruptive xanthoma. N Engl J Med 366:835

  5. Kuo CC et al (2011) Diabetic eruptive xanthoma. Acta Clin Belg 66:321-322
  6. Makdsi F et al (2010) Acute pancreatitis with eruptive xanthomas. J Hosp Med 5:115

  7. Merola JF et al (2008) Eruptive xanthomas. Dermatol Online J 14:10

  8. Seward JL et al (2004) Generalized eruptive histiocytosis. J Am Acad Dermatol 50: 116-120
  9. Vogl A et al (2005) Skin and alcohol. J Dtsch Dermatol Ges 3: 788-790
  10. Zahorcsek Z et al (1995) Successful treatment of eruptive xanthomatosis with Acipimox. Dermatologist 46: 124-126

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

Authors

Last updated on: 29.10.2020