Lipoprotein (a) hyperlipoproteinemia E78.4
Synonym(s)
lipoprotein(a) hyperlipipoproteinemia; lipoprotein(a) hyperlipoproteinemia; Lp(a) increase; Remnant hyperlipidemia
Etiopathogenesis
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In addition to LDL, Lp(a) contains ApoB-100, a plasminogen-like Apo(a), which competes with the plasminogen for the binding sites on the exothelial cells (antiplasminogenic effect). High Lp(a) may inhibit local fibrinolysis in the endothelial region of the vessels. Lp(a) concentrations >30mg/dl are considered an independent atherosclerosis risk factor.
Laboratory
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The serum is milky cloudy or clear, cholesterol and triglycerides are elevated. Lowering of the glucose tolerance threshold.
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Prof. Dr. med. Peter Altmeyer