HistoryThis section has been translated automatically.
DefinitionThis section has been translated automatically.
Clinically defined, non-syndromal, hereditary clinical picture with dystrophy of all (this definition is not tenable because not always 20 nails are changed) finger- and toenails (NDNC1). Here the nails are characterized by a rough, dull, sandpaper-like surface(trachyonychia). Other nail symptoms can also characterize this clinical picture.
You might also be interested in
Occurrence/EpidemiologyThis section has been translated automatically.
ManifestationThis section has been translated automatically.
In larger studies (n= 88) 2 manifestation peaks could be identified:
HistologyThis section has been translated automatically.
TherapyThis section has been translated automatically.
There is no known causal therapy for hereditary twenty-nail dystrophy.
In trachyonychia which occur in the context of underlying diseases, the treatment of the underlying disease is in the foreground; possibly short-term glucocorticoids under occlusion (e.g. glucocorticoid tinctures such as betamethasone in alcoholic-aqueous solution).
In case of resistance to therapy, the use of Ciclosporin A may be an alternative.
Otherwise, increased care of the nail plate.
Note(s)This section has been translated automatically.
The clinically descriptive term "trachyonychia" is also defined differently in different publications. It is probably a pathological expression pattern of the nail organ with very different trigger mechanisms.
Trachonyonychia can also occur reactively in various underlying diseases (e.g. psoriasis vulgaris, atopic eczema, lichen planus, alopecia areata).
LiteratureThis section has been translated automatically.
- Alkiewicz J (1950) Trachyonychia. Ann Dermatol Venereol 10: 136-140
- Braun-Falco O et al (1981) Trachyonychia: 20-nail dystrophy. Dermatologist 32: 17-22
- Chien P Jr et al (2008) Alopecia universalis with twenty-nail dystrophy (trachyonychia). Dermatol Online J 14:24
- Commens, C. A. Twenty-nail dystrophy in identical twins. Pediatrics. Derm. 5: 117-119, 1988
- Grover C et al (2003) Longitudinal nail biopsy: utility in 20-nail dystrophy. Dermatol Surg 29: 1125-1129
Khan S et al (2015) Genetics of human isolated hereditary nail disorders. Br J Dermatol 173:922-929.
- Lee YB et al (2012) Cyclosporine administration improves clinical manifestations and quality of life in patients with 20-nail dystrophy: case series and survey study. J Dermatol 39:1064-1065
- Wilson NJ et al (2013) Recessive mutations in the gene encoding frizzled 6 cause twenty nail dystrophy--expanding the differential diagnosis for pachyonychia congenita. J Dermatol Sci 70: 58-60
Incoming links (9)Alopecia areata unguium; Dystrophy, twenty nail dystrophy; Genetically caused non-syndromal nail abnormalities; Lichen planus of the nails; Onychodystrophy (overview); Pachyonychia congenita; Psoriasis of the nails; Trachyonychia idiopathica; Twenty-nail childhood dystrophy;
Outgoing links (9)Betamethasone; Ciclosporin a; Glucocorticosteroids; Nail; Parakeratosis; Spongiosis; Trachyonychia; Trachyonychia idiopathica; Twenty-nail childhood dystrophy;
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.