Syphilis connata A50.9

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

congenital syphilis; syphilis congenita; Syphilis congenital; syphilis connata

History
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Definition
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Extremely rare infectious disease caused by intrauterine transmitted syphilis. The time of transmission, the stage of the mother's disease and the number of pathogens is crucial for the clinical picture in the child.

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Etiopathogenesis
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  • Florid early syphilis in the mother: diaplacental transfer of the pathogen to the fruit (4th to 5th month of pregnancy): In the 7th to 8th month of pregnancy, syphilitic stillbirth occurs in 80-90% of cases.
  • Florid late acquired syphilis of the mother: Living child with syphilis connata.
  • Late syphilis of the mother: birth of a healthy child is possible. Infection of the child through the birth process is possible.

Clinical features
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Diagnosis
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Pathogen detection, positive syphilisserology.

Differential diagnosis
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Therapy
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  • Syphilis congenita precox: Benzylpenicillin (e.g. Penicillin GrĂ¼nenthal) 2-3 times/day 50.000 IU/kg i.v. in 4-6 ED. Therapy duration: 14 days. With CNS involvement: benzathine benzylpenicillin (e.g. Tardocillin 1200) 3 doses at weekly intervals with 20,000 IU/kg bw i.v. each time. Alternatively ceftriaxone (Rocephin): infants > 2 weeks/children < 12 years.: once/day 20-100 mg/kg bw i.v.
  • Syphilis congenita tarda: From the 2nd year of life onwards, treatment is the same as for acquired late syphilis in adults without CNS involvement, see below. Syphilis acquisita.

Progression/forecast
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Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020