Praziquantel

Last updated on: 29.10.2020

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Definition
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Broadband anthelmintic.

Half-life
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1–1,5 h

Effects
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Vermicide by spastic paralysis of the worm muscles, glucose and glycogen depletion.

Indication
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Bilharzia (S. haematobium, S. mansoni, S. intercalatum, S. japonicum, S. mekongi), liver flukes (e.g. Clonorchis sinensis, Opisthorchis viverrini, O. felineus), pulmonary flukes (Paragonimus westermani anda. spp.), taeniasis, neurocysticercosis, Hymenolepis nana (dwarf tapeworm), Diphyllobothrium pacificum (South American fish tapeworm) (see tapeworms)

Limited indication
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Restricted kidney function, cardiac arrhythmia, heart failure requiring digitalis.

Dosage and method of use
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See Table 1.

Note!

The therapy of cysticercosis should be carried out as an in-patient!

Undesirable effects
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Abdominal pain, nausea, vomiting, headaches, dizziness, weakness, fatigue, urticaria, temperature rise, urticaria, difficulty swallowing, possibly chest tightness

Interactions
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Carbamazepine, cimetidine, dexamethasone and phenytoin lead to a reduction of the praziquantel level.

Contraindication
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Pregnancy, breastfeeding (up to 48 hours after taking the tablet), ocular cysticercosis, liver diseases.

Preparations
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Biltricides, Cesol, Cysticides

Patientinformation
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Remember! The tablets cause a restriction of the ability to react!

Tables
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Dosages of Praziquantel

Indication

Dosage

Leech

Clonorchis, Dicrocoellum, Fasciolopsis, Herterophyer, Metagonism, Opisthorchis

3 times 25 mg/kg KG p.o. as ED

Paragonism

3 times 25 mg/kg bw/day for 2 days

Coupled sails (schistosomes)

Sch. haematobium, intercalatum, mansoni

2 times 20 mg/kg bw/day as ED

Sh. japonicum

3 times 20 mg/kg bw or 30 mg/kg bw as ED

Sh. Mekongi

Tapeworms

Diphyllobothrium latum

15 mg/kg bw as ED

dipylidium caninum

25 mg/kg bw as ED

Hymenolepis nana and diminuta

25 mg/kg bw as ED

saginata taenia

10 mg/kg bw/day for 1-3 days

taenia solium

10 mg/kg bw/day for 1-3 days

Cysticercosis

Cysticercosis (except intraocular cysticercosis)

50 mg/kg bw/day for 15 days

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Last updated on: 29.10.2020