Praziquantel

Definition
This section has been translated automatically.

Broadband anthelmintic.

Half-life
This section has been translated automatically.

1–1,5 h

You might also be interested in

Dermatology

Cysticercosis

Disease caused by fins (especially of the porcine tapeworm).

Advertisment

Pharmacodynamics (Effect)
This section has been translated automatically.

Vermicide by spastic paralysis of the worm muscles, glucose and glycogen depletion.

Indication
This section has been translated automatically.

Bilharzia (S. haematobium, S. mansoni, S. intercalatum, S. japonicum, S. mekongi), liver flukes (e.g. Clonorchis sinensis, Opisthorchis viverrini, O. felineus), pulmonary flukes (Paragonimus westermani anda. spp.), taeniasis, neurocysticercosis, Hymenolepis nana (dwarf tapeworm), Diphyllobothrium pacificum (South American fish tapeworm) (see tapeworms)

Limited indication
This section has been translated automatically.

Restricted kidney function, cardiac arrhythmia, heart failure requiring digitalis.

Dosage and method of use
This section has been translated automatically.

See Table 1.

Note!

The therapy of cysticercosis should be carried out as an in-patient!

Undesirable effects
This section has been translated automatically.

Abdominal pain, nausea, vomiting, headaches, dizziness, weakness, fatigue, urticaria, temperature rise, urticaria, difficulty swallowing, possibly chest tightness

Interactions
This section has been translated automatically.

Carbamazepine, cimetidine, dexamethasone and phenytoin lead to a reduction of the praziquantel level.

Contraindication
This section has been translated automatically.

Pregnancy, breastfeeding (up to 48 hours after taking the tablet), ocular cysticercosis, liver diseases.

Preparations
This section has been translated automatically.

Biltricides, Cesol, Cysticides

Patientinformation
This section has been translated automatically.

Remember! The tablets cause a restriction of the ability to react!

Tables
This section has been translated automatically.

Dosages of Praziquantel

Indication	Dosage
Leech
Clonorchis, Dicrocoellum, Fasciolopsis, Herterophyer, Metagonism, Opisthorchis	3 times 25 mg/kg KG p.o. as ED
Paragonism	3 times 25 mg/kg bw/day for 2 days
Coupled sails (schistosomes)
Sch. haematobium, intercalatum, mansoni	2 times 20 mg/kg bw/day as ED
Sh. japonicum	3 times 20 mg/kg bw or 30 mg/kg bw as ED
Sh. Mekongi	3 times 20 mg/kg bw or 30 mg/kg bw as ED
Tapeworms
Diphyllobothrium latum	15 mg/kg bw as ED
dipylidium caninum	25 mg/kg bw as ED
Hymenolepis nana and diminuta	25 mg/kg bw as ED
saginata taenia	10 mg/kg bw/day for 1-3 days
taenia solium	10 mg/kg bw/day for 1-3 days
Cysticercosis
Cysticercosis (except intraocular cysticercosis)	50 mg/kg bw/day for 15 days