Dexamethasone

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

9-Fluor-11β,17,21-trihydroxy-16α-methyl-pregna-1,4-dien-3,20-dion; Dexamethasone; Oradexone

Definition
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Medium strength halogenated glucocorticoid.

Half-life
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3–5 h

Indication
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Allergic diseases, topical for allergic skin reactions and eczema, emergencies such as anaphylactic shock, status asthmaticus, brain edema.

Dosage and method of use
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  • Eye drops: Apply 2 times/day in the conjunctival sac.
  • Creams / Ointments: Apply thinly 1-3 times/day to the affected skin areas.
  • Solutions/Crinals: Apply a thin layer 1-3 times/day to the affected areas of skin.
  • Systemic: Initially 0.75-16 mg in the morning, then reduction to 1-1.5 mg/day p.o., i.v. or i.m. In emergencies (cerebral edema, anaphylactic shock): Initially 40-100 mg i.v., then 4-8 mg i.v. or i.m. in 2-4 hours intervals over about 8 days. Status asthmaticus: 4-20 mg initial i.v., if necessary another 8-10 mg i.v.

Standard concentration
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0.1% eye drops, 0.3-1% in creams and ointments, 0.25-0.3% in solutions

Contraindication
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I.m. injection for idiopathic thrombocytopenic purpura, i.v. injection of crystal suspension.

Recipe(s)
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Preparations
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Fortecortin, dexamethasone Jenapharm, cortidexasone, Dexa Hexal

Authors

Last updated on: 29.10.2020