Interferon gamma

Authors: Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

All authors of this article

Last updated on: 29.10.2020

Dieser Artikel auf Deutsch

Synonym(s)

gamma interferon; gamma-interferon; IFN gamma; IFN-gamma; IFN γ; IFN-γ; INF gamma; Interferon-gamma; Interferon-γ; γ Interferon

Definition
This section has been translated automatically.

Half-life
This section has been translated automatically.

5 h

Pharmacodynamics (Effect)
This section has been translated automatically.

Induction of IL 2 production in T-helper cells. Expression of HLA class II antigens. Stimulation of monocytes and macrophages for TNF α production. Induction of the expression of IgG receptors on neutrophil granulocytes.

Indication
This section has been translated automatically.

Therapeutic use with:

Chronic granulomatous diseases, leprosy, visceral leishmaniasis, infections with atypical mycobacteria in patients with CD 4-positive T cells deficiency.

Also in: rheumatoid arthritis, renal cell carcinoma, malignant melanoma, Schmincke tumors, CML, hairy cell leukemia, myelodysplastic syndrome, acute leukemia.

Limited indication
This section has been translated automatically.

Pregnancy, nursing.

Dosage and method of use
This section has been translated automatically.

Pat. > 0,5 m2 KO: 3 times/week 50 μg s.c., Pat. < 0,5 m2 KO: 3 times/week 1,5 μg/kg KG.

Undesirable effects
This section has been translated automatically.

Flu-like symptoms, dyshidrosis, dyspnoea, BB changes, transaminase increase, acute kidney failure, photosensitization, confusion, visual disturbances.

Interactions
This section has been translated automatically.

Fluorouracil leads to a mutual enhancement of the effect.

Contraindication
This section has been translated automatically.

Pregnancy, hypersensitivity to human serum albumin, autoimmune diseases, severe liver and kidney dysfunction.

Preparations
This section has been translated automatically.

Imukin